Impact of preanalytical factors on liquid biopsy in the canine cancer model
Studies in dogs with natural cancer show blood sampling location affects tumor DNA results and that longitudinal monitoring detects relapse early.
Broad Institute study using dogs with spontaneous cancer demonstrates that blood draw site influences cfDNA tumor fraction and that longitudinal cfDNA monitoring detects impending relapse before clinical signs, supporting the canine model as a rapid validation platform for human liquid biopsy optimization.
What the study was
- Study design
- Translational animal model study
- Population
- Pet dogs with spontaneous cancer (lymphoma, osteosarcoma)
- Category
- Diagnostics
- Maturity
- Exploratory
- Journal
- Communications Medicine
Why it surfaced
Non-human model (score capped per rubric); translational preanalytical liquid biopsy data from Broad Institute.
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