Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets
Sleep and AQP4-targeting drugs emerge as convergent strategies for restoring brain fluid clearance in aging and neurological disease.
Huazhong University review integrates glymphatic system biology with aging and neurological disease, mapping AQP4-mediated CSF/ISF exchange dysfunction as a bidirectional neurodegeneration driver. Sleep optimization, AQP4 pharmacology, and non-invasive physical interventions are identified as convergent strategies for disease modification in aging brains.
What the study was
- Study design
- Narrative review
- Population
- Neurological disease populations (Alzheimer's, Parkinson's, stroke)
- Category
- Other
- Maturity
- Exploratory
- Journal
- Molecular Biomedicine
Why it surfaced
Glymphatic-aging nexus is active mechanistic frontier; AQP4 therapeutic targeting emerging area.
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