Sex differences in cancer incidence among people with HIV infection in the United States
Sex-based cancer disparities among HIV-positive people largely vanished, implicating immune dysfunction over behavior as the primary driver.
In 3.9 million person-years of HIV-cancer registry linkage, sex-based cancer incidence disparities were substantially attenuated for 9 cancer types in HIV+ people, implicating immune dysregulation over behavioral factors as a driver of sex-based cancer risk. These findings challenge assumptions about the biology of sex disparities in cancer.
What the study was
- Study design
- Population-based HIV-cancer registry linkage study (2001–2019)
- Population
- People with HIV (US registry linkage)
- Category
- Public Health
- Maturity
- Validated
- Journal
- Journal of the National Cancer Institute
Why it surfaced
Large JNCI NCI registry study; immunological insight into sex-based cancer risk disparities including DLBCL.
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