The dual balance of the cytokine network: key messengers of immune activation and triggers of cytokine storm
New therapies targeting disrupted immune signaling in cancer and infection show growing promise, from antibodies to CAR-T cells adapted to cytokine pathways.
This comprehensive review in Biomarker Research synthesizes current knowledge of the cytokine network's dual homeostatic balance and its disruption in major diseases including cancer, sepsis, and autoimmune conditions. It evaluates emerging therapeutic strategies including monoclonal antibodies, JAK inhibitors, bispecific antibodies, and CAR-T cell therapies targeting cytokine pathways.
What the study was
- Study design
- Narrative review
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Biomarker Research
Why it surfaced
Broad synthesis of immunotherapy landscape relevant to T6 watchlist. High-impact journal (Biomark Res); review only, no new primary data.
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