📅 PUBMED DAILY TRIAGE — 2026-06-15 (Monday)
Window: 2026-06-14T09:00Z → 2026-06-15T09:00Z (CRDT) — ⚠️ 48H EXPANSION TRIGGERED Topics scanned: 9 + sentinel | Candidates reviewed: ~75 | Articles classified: 13 STANDARD + 6 LOW High priority: 0 | Standard: 13 | Low/archive: 6 | Unsolicited finds: 1 Run status: SUCCESS (window expanded to 48h; 24h window returned 0 — Monday PubMed lag confirmed)
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
No HIGH priority articles this run.
Topic coverage:
- Hematologic malignancies: No HIGH (best: TR-2026-06-15-001, 7/10)
- CBC-based diagnostics/ML: No HIGH (0 results — T2 zero-volume streak continues)
- Liquid biopsy/ctDNA: No HIGH (best: TR-2026-06-15-009, 4/10)
- AI/ML diagnostics/imaging: No HIGH (best: TR-2026-06-15-004, 5/10)
- Precision oncology/genomics: No HIGH (best: TR-2026-06-15-005, 5/10)
- Novel therapeutics: No HIGH (best: TR-2026-06-15-001, 7/10 — shared)
- Cardiovascular-metabolic: No HIGH (best: TR-2026-06-15-003/006/007, 5/10 — T7 zero-HIGH day 4)
- Aging/longevity: No HIGH (T8 zero-HIGH day 5)
- Rare diseases: No HIGH (best: TR-2026-06-15-012 sentinel, 4/10)
🟢⚪ STANDARD (4-7) — Top by Topic
Hematologic Malignancies + Novel Therapeutics (CAR-T)
- TR-2026-06-15-001 · PMID 42286658 · Late phase transfusion after CAR T therapy associated with persistent hematotoxicity and NRM in multiple myeloma · 7/10 · Retrospective n=155 R/R MM: late RBC transfusion (>30 days) → median OS 10.87 vs 37.87 months (P<0.0001); first systematic characterization of late transfusion as independent prognostic marker in CAR-T-treated MM. (BMC Med)
- TR-2026-06-15-002 · PMID 42286724 · Dual-target CAR-T cell therapy: latest updates from 2025 ASH annual meeting · 6/10 · ASH 2025 summary covering CD19/CD22, CD19/CD20, CD123/CD33 dual-target approaches in B-cell malignancies, AML, autoimmune; logic-gated designs address antigen escape. (Exp Hematol Oncol, Letter)
- TR-2026-06-15-003 · PMID 42286660 · CVD co-listing on cancer death certificates, US 1999-2020 (56M death certs) · 5/10 · Leukemia highest CVD co-listing in young adults (PMR 2.174); PMRs rising across all age groups 1999-2020 (AAPC 1.69%); novel PMR surveillance framework. (Cardio-oncology)
- TR-2026-06-15-008 · PMID 42286808 · Belantamab mafodotin+BortVD vs SoC in ≥3L R/R MM (ITC) · 4/10 · Comparative efficacy letter (DREAMM-7 ITC); GSK-sponsored. (Am J Hematol, Letter)
AI/ML Diagnostics + Imaging
- TR-2026-06-15-004 · PMID 42287031 · 3D portal vein geometry predicts post-TIPS hepatic encephalopathy and variceal rebleeding (multicenter n=579) · 5/10 · 3D-CGM C-index 0.801 (OHE) and 0.792 (VRB) vs clinical-only 0.715/0.686; non-invasive imaging biomarker from routine CT. (Liver Int)
- TR-2026-06-15-013 · PMID 42287017 · Australian MRI Linac program review: AI image enhancement, radiotherapy targeting · 4/10 · Program review; 120+ papers, AI-enhanced adaptive radiotherapy; historical. (J Med Imaging Radiat Oncol)
Precision Oncology / Genomics
- TR-2026-06-15-005 · PMID 42287060 · NGS molecular characteristics of RCC with lymph metastases (n=52, Peking Univ) · 5/10 · VHL/PBRM1/SETD2 dominant mutations; IGF2R, JUN, EPHA5, FH associated with poor prognosis; lymph nodes as 'metastatic pool'. (Beijing Da Xue Xue Bao)
- TR-2026-06-15-009 · PMID 42286810 · Vorasidenib in IDH2-mutant cholangiocarcinoma with ctDNA monitoring (case report) · 4/10 · Off-label IDH1/2 inhibitor achieves durable RECIST PR + ctDNA reduction ~1 year in post-transplant patient; hypothesis-generating for IDH-targeted CCA expansion. (The Oncologist)
Cardiovascular-Metabolic
- TR-2026-06-15-006 · PMID 42286669 · TyG index and kidney stone disease meta-analysis (n=1,066,215; 14 studies) · 5/10 · Linear dose-response: each TyG unit increment → 33% higher KSD odds; highest quintile 52% higher odds; actionable for cardiometabolic risk screening. (Lipids Health Dis)
- TR-2026-06-15-007 · PMID 42286980 · Metabolic surgery in GLP-1 era: upfront toll vs long-term dividend · 5/10 · Expert perspective on surgery vs GLP-1 RA tradeoffs; references 2025 Nature Medicine comparative outcomes data. (Obesity Silver Spring)
- TR-2026-06-15-011 · PMID 42286783 · Omega-6/omega-3 ratio, BMI, depression in young Iranian adults (n=440) · 4/10 · Very large OR for omega-6/3 ratio and depression (OR 9.94); cross-sectional caution applies. (J Health Popul Nutr)
Novel Therapeutics
- TR-2026-06-15-010 · PMID 42287073 · Poxvirus viral vector manufacturing review with AI optimization · 4/10 · 2-log yield improvement with AI-optimized continuous purification; cancer vaccine manufacturing context. (Expert Rev Vaccines)
💡 UNSOLICITED FINDS
- TR-2026-06-15-012 · PMID 42287114 · Limits of viability: are we heading in right direction? · 4/10 · Public Health/Rare · Review critically contextualizing periviable birth survival thresholds as health-system-capacity constructs; marked HIC/LMIC survival disparities; SDG-aligned equity framing. Captured via sentinel. (J Perinat Med)
📊 TODAY'S BREAKDOWN
By research category:
- Treatment Innovation: 4 (TR-001, TR-002, TR-009, TR-010)
- Diagnostics: 3 (TR-004, TR-005, TR-006)
- Public Health: 2 (TR-003, TR-012)
- Prevention: 2 (TR-006, TR-007)
- Genomics/Precision Medicine: 1 (TR-005)
- Drug Development: 1 (TR-010)
By evidence maturity:
- Validated: 4 (TR-001, TR-003, TR-004, TR-006)
- Exploratory: 9
By watchlist topic (reviewed / new-kept / highest score):
| Topic | Reviewed | New Kept | Highest Score |
|---|---|---|---|
| Hematologic malignancies | 10 | 4 | 7 |
| CBC/ML diagnostics | 0 | 0 | — |
| Liquid biopsy/ctDNA | 3 | 1 | 4 |
| AI/ML diagnostics | 10 | 3 | 5 |
| Precision oncology | 10 | 2 | 5 |
| Novel therapeutics | 10 | 3 | 7 |
| Cardiovascular-metabolic | 9 | 3 | 5 |
| Aging/longevity | 3 | 0 | 3 |
| Rare diseases | 3 | 1* | 4 |
| Sentinel | 10 | 1 | 4 |
*via sentinel overlap
By source type: peer_reviewed: 13 | preprint: 0
Topics with zero 8+ articles this run: ALL topics (no HIGH articles found in this run)
🔧 RUN NOTES
- ⚠️ 48H WINDOW EXPANSION TRIGGERED: 24h window (2026-06-14 to 2026-06-15) returned 0 results confirmed across broad queries. PubMed has not yet ingested a new batch for June 14. This is a recurring Monday pattern — weekend batches are unavailable at 09:00 UTC Monday. Window expanded to 48h (2026-06-13 to 2026-06-15) per protocol. Articles captured are from June 13 CRDT batch not retrieved by yesterday's specific queries.
- Recommendation: Consider shifting Monday run time to 14:00 UTC to capture the weekend processing batch before triage.
- T2 (CBC/ML): Zero results in both 24h and 48h windows. Query broadening recommended — suggest adding "peripheral blood" OR "blood differential" OR "morphology" as alternative CBC-related terms.
- T7 (Cardiovascular-metabolic): No HIGH articles for 4th consecutive day. Topic continues to yield STANDARD content; no systematic issue identified.
- T8 (Aging/longevity): No HIGH articles for 5th consecutive day. humans[MeSH] filter is working (no insect/animal noise this run) but returning policy, social, and institutional articles rather than biology. Consider adding
AND (senolytic OR "epigenetic clock" OR "biological aging" OR telomere OR proteostasis OR "cellular senescence")to T8 query. - No HIGH priority alerts emitted this run (0 articles scored ≥8; no EARLY_CANCER_DETECTION or NOVEL_TREATMENT flag triggers).
- Low/archive articles not formally classified (count only): 42287064 (BML/SLE case, score 3), 42286984 (lineage infidelity LBCL, no abstract, score 3), 42286836 (Melbourne ageing research collaboration, score 3), 42287075 (Medicaid estate recovery NC, score 3), 42287042 (intussusception epidemiology China, score 3), 42286745 (vaginal cuff dehiscence case, score 2).