Innate immune dysregulation in multiple myeloma: molecular basis and mechanistic interventions.
A systematic review maps how multiple myeloma disables immune defenses and identifies therapeutic strategies to restore them, guiding next-generation immunotherapy development.
This review systematically maps the mechanisms by which multiple myeloma subverts innate immunity — including NK cell exhaustion, macrophage polarization, and complement evasion — and the current therapeutic strategies to restore innate immune function. Relevant to emerging immunotherapy and bispecific antibody strategies in MM.
What the study was
- Study design
- Narrative review
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- International Immunopharmacology
Why it surfaced
Solid mechanistic review in a relevant journal; supports downstream MM immunotherapy topic coverage.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.