📅 PUBMED DAILY TRIAGE — 2026-06-19
Window: 2026-06-18T09:00Z → 2026-06-19T09:00Z (CRDT) Topics scanned: 9 | Articles reviewed: ~114 candidates | Kept: 12 High priority: 2 | Standard: 10 | Low/archive: 0 | Unsolicited finds: 0 Run status: ⚠️ PARTIAL_SUCCESS (T9 rare diseases + sentinel scan summaries not fetched)
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
T5/T6 — Precision Oncology & Novel Therapeutics
TR-2026-06-19-001 / PMID 42314664 · Targeting TROP2 in drug-tolerant persister cells delays EGFR TKI resistance in NSCLC · 8/10 · 🟠 NOVEL_TREATMENT
Cancer Cell paper demonstrating TROP2 upregulation in EGFR TKI drug-tolerant persister cells in NSCLC, with TROP2-directed targeting delaying acquired resistance — provides mechanistic rationale for TROP2 ADC + EGFR TKI combination trials immediately.
TR-2026-06-19-002 / PMID 42315499 · Spatially interpretable AI framework for neoadjuvant dual HER2 blockade in HER2+ breast cancer · 8/10 · 🟠 NOVEL_TREATMENT
Signal Transduct Target Ther (IF ~40) study of spatially interpretable AI predicting pCR to neoadjuvant HER2 blockade — addresses a validated unmet clinical need in HER2+ breast cancer with near-term implementability.
T1 — Hematologic Malignancies
T1: No high-priority finds today (best candidate scored 6/10 — CAR-T disparities)
T2 — CBC/ML Hematology
T2: No high-priority finds today (best 6/10 via fallback — MC-80 digital morphology validation)
T3 — Early Cancer Detection
T3: No high-priority finds today (best 5/10 — UTUC liquid biopsy review)
T4 — AI/ML Diagnostics
T4: Best HIGH article was PMID 42315499 (shared with T5/T6); best T4-exclusive was 7/10 LLM AI agent for PET/CT
T7 — Cardiovascular-Metabolic
T7: No high-priority finds today (best 7/10 — ESG meta-analysis n=8,880)
T8 — Aging/Longevity
T8: No high-priority finds today (best 5/10 — physical activity in older HIV patients SR)
T9 — Rare Diseases
T9: ⚠️ UNREVIEWED — 38 results found, summaries not fetched this run. Priority check next run.
🟢⚪ STANDARD (5–7) — Top by Topic
T1 — Hematologic Malignancies
- TR-2026-06-19-005 / 42315023 · Trends and Disparities in CAR-T Therapy 2017-2022 (US) · 6/10 · Treatment Innovation | 🟡 UNDERSERVED_POPULATION
- TR-2026-06-19-007 / 42314557 · Innate immune dysregulation in MM: molecular basis and mechanistic interventions · 5/10 · Review | Int Immunopharmacol
- TR-2026-06-19-008 / 42314682 · Quantitative molecular cartography of emergency myelopoiesis · 5/10 · Cell Stem Cell | ⚪ PROMISING_PRELIMINARY
- TR-2026-06-19-012 / 42315465 · Cardiotoxicity recommendations for pediatric acute leukemia (SFCE guideline) · 5/10 · Practice Guideline | 🟢 NEAR_TERM_IMPLEMENTABLE
T2 — CBC/ML Hematology
- TR-2026-06-19-006 / 42309506 · Clinical Validation of MC-80 Digital Morphology Analyzer in Leukocyte Classification · 6/10 · Validation Study | Int J Lab Hematol | 🟢 NEAR_TERM_IMPLEMENTABLE
T3 — Early Cancer Detection
- TR-2026-06-19-009 / 42311269 · Liquid biopsy-guided kidney-sparing management in UTUC · 5/10 · Review | Front Oncol
T4 — AI/ML Diagnostics
- TR-2026-06-19-004 / 42315314 · End-to-End PET/CT Interpretation with LLM-Orchestrated AI Agent (real-world pilot) · 7/10 · J Nucl Med | ⚪ PROMISING_PRELIMINARY
- TR-2026-06-19-010 / 42315311 · AI-Enhanced RV Perfusion Quantification on PET/CT · 5/10 · J Nucl Med | multicenter
T7 — Cardiovascular-Metabolic
- TR-2026-06-19-003 / 42315493 · Endoscopic Sleeve Gastroplasty Efficacy Meta-Analysis, n=8,880 · 7/10 · Diabetes Obes Metab | Meta-Analysis
T8 — Aging/Longevity
- TR-2026-06-19-011 / 42311983 · Physical activity facilitators/barriers in older HIV adults — systematic review · 5/10 · Front Public Health | 🟡 UNDERSERVED_POPULATION
💡 UNSOLICITED FINDS
None today (sentinel scan IDs retrieved but summaries not reviewed — coverage gap logged).
📊 TODAY'S BREAKDOWN
By research category:
- Treatment Innovation: 4
- Diagnostics: 4
- Genomics/Precision Medicine: 1
- Public Health: 1
- Prevention: 1
- Early Detection: 1
By evidence maturity:
- Validated: 6
- Exploratory: 6
By watchlist topic (reviewed / kept / highest score):
| Topic | Raw Results | Reviewed | Kept | Best Score |
|---|---|---|---|---|
| T1 Hematologic | 81 | 14 | 4 | 6 |
| T2 CBC/ML | 0+1 fallback | 1 | 1 | 6 |
| T3 Liquid biopsy | 23 | 7 | 1 | 5 |
| T4 AI/ML Diagnostics | 123 | 6 | 3 | 8 |
| T5 Precision Oncology | 107 | 8 | 2 | 8 |
| T6 Novel Therapeutics | 90 | 9 | 3 | 8 |
| T7 Cardiometabolic | 283 | 7 | 1 | 7 |
| T8 Aging | 23 | 6 | 1 | 5 |
| T9 Rare Diseases | 38 | ⚠️ 0 | 0 | — |
| Sentinel | 1055 | ⚠️ 0 | 0 | — |
By source type: peer_reviewed: 12 | preprint: 0
Topics with ZERO 8+ articles this run: T1, T2, T3, T7, T8, T9 (T9 unreviewed)
Topics with HIGH (8+) articles: T4 (1), T5 (1), T6 (2) — note T5/T6 overlap means 2 unique HIGH articles
🔧 RUN NOTES
T9 UNREVIEWED (coverage gap): T9 rare disease search returned 38 results and top 20 IDs were retrieved but esummary batch not fetched. Top IDs for priority check next run: 42315977, 42315827, 42315747, 42315278, 42315270. This is a PARTIAL_SUCCESS designation driver.
Sentinel scan IDs retrieved but not reviewed: 1,055 results; top 10 IDs logged (42312823, 42312825, 42312728, 42312044, 42313755, 42315646, 42313091, 42315354, 42311049, 42311388). IDs 42312823/42312825 appeared in T3.
T2 zero-signal in 24h window (day 1 of new streak): Primary T2 query returned 0 results for 2026-06-18:2026-06-19 window. Fallback (extended to 2026-06-17) found PMID 42309506 (CRDT 2026-06-17). This article was already in the T2 fallback window covered by prior run, but not previously flagged. Zero-signal streak tracking reset; watch streak counter carefully over next 3 days.
T1 zero-HIGH streak: Day 2. Best T1 article today was 6/10 (CAR-T disparities). T1 has not produced a score-8+ article in 2 consecutive days.
T7 zero-HIGH streak: Day 2. Largest T7 dataset (283 results) but dominated by diabetes/metabolic noise; best was 7/10 meta-analysis.
T8 zero-HIGH streak: Day 2. humans[MeSH] filter applied per instruction; 23 results, best 5/10.
T4 HIGH streak broken: T4 produced its first HIGH article (PMID 42315499 — shared with T5/T6) after 2-day zero-HIGH streak.
T3 continues zero-HIGH streak (Day 5+): No T3-specific HIGH articles in 5+ days; batch dominated by Cureus case reports and Front Oncol reviews. Consider query refinement for T3.
Deferred PMID 42310469 resolved: Wound healing/oregano polymer coating (Int Wound J) — discarded, zero watchlist relevance.
Truncation in multiple esummary batches: T1 (14/20 IDs unreviewed), T4/T5/T6 (partial coverage). Top IDs in these truncated batches may contain additional STANDARD articles.