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20 papers read · 20 surfaced · 3 stood out

Today's lead · Treatment Innovation

Non-myeloablative versus reduced intensity conditioning for…

Choosing peripheral blood stem cells over bone marrow grafts may improve survival odds for older patients with AML undergoing transplant.

Kanellopoulos A, Labopin M, Spyridonidis A et al. · Bone Marrow Transplantation

Read the deep dive → Read the breakdown

9/10

Impact score

How it scored

Novelty2

Clinical relevance3

Study quality2

Population & unmet need2

Time to impact (est.)

Lab
Preclinical
Early trials
Late trials
In practice

Near-term implementable finding

An indirect comparison of pirtobrutinib with second-generation…

Pirtobrutinib offers a heart-safer alternative to some older BTK inhibitors for treating chronic lymphocytic leukemia without loss of efficacy.

Leukemia & Lymphoma · Score 8/10 · ◆ deep dive

Early cancer detection or prevention

Preoperative Tumor-Informed ctDNA for Prediction of Nodal Metastases…

A simple blood test before bladder cancer surgery may safely identify patients who can skip lymph node removal, reducing surgical side effects.

Annals of Surgical Oncology · Score 8/10 · ◆ deep dive

Promising but preliminary

Machine learning-guided risk stratification in elderly AML based on…

Machine learning combining genetic and immune markers helps predict which elderly AML patients will respond best to treatment.

BMC Geriatrics · Score 7/10 · ◆ deep dive

Novel or significantly improved treatment

Phase I study of oral azacitidine plus salvage chemotherapy in…

Combining oral azacitidine with salvage chemotherapy is feasible and safe for aggressive lymphoma patients preparing for transplant.

Annals of Hematology · Score 7/10