Real-world prevalence of actionable genomic alterations detected by next-generation sequencing in non-small cell lung cancer: a systematic review and meta-analysis.
Systematic review quantifies real-world frequency of actionable genetic mutations in lung cancer, informing expectations for precision testing benefits.
This systematic review and meta-analysis characterizes real-world NGS detection rates of actionable genomic alterations in NSCLC, providing a comprehensive landscape of driver mutation frequencies across ethnicities and regions. Results directly inform tumor testing guidelines and help quantify expected return from comprehensive genomic profiling in NSCLC practice.
What the study was
- Study design
- Systematic review and meta-analysis
- Population
- NSCLC patients in real-world settings with NGS testing
- Category
- Genomics/Precision Medicine
- Maturity
- Validated
- Journal
- Clinical and Translational Oncology
Why it surfaced
Meta-analysis of real-world NGS actionable alteration rates in NSCLC; directly relevant for precision oncology policy and guideline development; Clin Transl Oncol Spanish Oncology federation journal.
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