A Primate-Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1-Dependent Destabilization of RBMX.
A human-specific gene involved in aging regulates a protein pathway, suggesting a novel target for developing aging interventions specific to humans.
This Aging Cell study identifies LINC01021, a primate-specific long non-coding RNA, as a regulator of cellular and organismal aging by destabilizing the RNA-binding protein RBMX via DAZAP1. The primate-specific nature of this pathway suggests it may contribute to human-specific aging trajectories and could represent a novel target for aging intervention.
What the study was
- Study design
- Functional molecular study: primate-specific lncRNA in cellular and organismal aging models
- Population
- Human cell models + primate/mouse aging models
- Category
- Genomics/Precision Medicine
- Maturity
- Exploratory
- Journal
- Aging Cell
Why it surfaced
Novel primate-specific lncRNA aging pathway; Aging Cell; open-access PMC; primate-specificity increases translational potential for human aging biology.
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