PubMed Daily Triage - 2026-06-27

Run status: SUCCESS
Window: 2026-06-26T00:00:00Z to 2026-06-27T23:59:59Z
Articles reviewed: 169 | HIGH: 14 | STANDARD: 62 | LOW: 93

High Priority

1. Circulating Cell-Free DNA Analysis for Diagnostic and Prognostic Assessment of Hepatocellular Carcinoma in Cirrhosis

PMID: 42353299 | Journal: International journal of molecular sciences | Score: 9/10 Topics: T3 - Early Cancer Detection

Circulating Cell-Free DNA Analysis for Diagnostic and Prognostic Assessment of Hepatocellular Carcinoma in Cirrhosis.

This cohort/real-world study was triaged for T3 - Early Cancer Detection based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with moderate evidence maturity.

2. Pola-R-CHP as frontline therapy for diffuse large B-cell lymphoma: a systematic review and meta-analysis of randomized trials and real-world evidence

PMID: 42362499 | Journal: Blood cancer journal | Score: 9/10 Topics: T1 - Hematologic Malignancies

Meta-analysis of randomized and real-world Pola-R-CHP evidence in frontline DLBCL.

This meta-analysis was triaged for T1 - Hematologic Malignancies based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with stronger evidence maturity.

3. OncoGen.AI: an integrated platform for automated genomic analysis and reporting in precision oncology

PMID: 42362719 | Journal: NPJ precision oncology | Score: 9/10 Topics: T5 - Precision Oncology/Genomic Medicine

OncoGen.AI: an integrated platform for automated genomic analysis and reporting in precision oncology.

This cohort/real-world study was triaged for T5 - Precision Oncology/Genomic Medicine based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with moderate evidence maturity.

4. Efficacy and safety of orforglipron in obesity with type 2 diabetes mellitus: a GRADE-assessed meta-analysis of randomized controlled trials

PMID: 42363271 | Journal: Diabetology & metabolic syndrome | Score: 9/10 Topics: T7 - Cardiovascular-metabolic GLP-1/SGLT2

GRADE-assessed meta-analysis of randomized orforglipron trials in obesity with type 2 diabetes.

This meta-analysis was triaged for T7 - Cardiovascular-metabolic GLP-1/SGLT2 based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with stronger evidence maturity.

5. Cell type-specific contextualisation of the human phenome: towards the systematic treatment of all rare diseases

PMID: 42363298 | Journal: Genome medicine | Score: 9/10 Topics: T9 - Rare Diseases

The article reports cell type-specific contextualisation of the human phenome: towards the systematic treatment of all rare diseases.

This diagnostic/model validation study was triaged for T9 - Rare Diseases based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with moderate evidence maturity.

6. Comparative Analysis of Serum and Tissue miRNA Expression Profiles and Regulatory Pathways in Early-Stage Ovarian Cancer Using Public Databases

PMID: 42353343 | Journal: International journal of molecular sciences | Score: 8/10 Topics: T3 - Early Cancer Detection

Comparative Analysis of Serum and Tissue miRNA Expression Profiles and Regulatory Pathways in Early-Stage Ovarian Cancer Using Public Databases.

This diagnostic/model validation study was triaged for T3 - Early Cancer Detection based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with moderate evidence maturity.

7. Frequency-Domain Transformation of cfDNA End-Motif Profiles Enhances Robust Cancer Detection

PMID: 42353820 | Journal: Genes | Score: 8/10 Topics: T3 - Early Cancer Detection

The article reports frequency-Domain Transformation of cfDNA End-Motif Profiles Enhances Robust Cancer Detection.

This journal article was triaged for T3 - Early Cancer Detection based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with limited evidence maturity.

8. Expanding the clinical and molecular spectrum of NGLY1 deficiency: A multicenter cohort

PMID: 42361657 | Journal: Molecular genetics and metabolism | Score: 8/10 Topics: T9 - Rare Diseases

Expanding the clinical and molecular spectrum of NGLY1 deficiency: A multicenter cohort.

This cohort/real-world study was triaged for T9 - Rare Diseases based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with moderate evidence maturity.

9. Inhibition of ADSS2-mediated de novo AMP biosynthesis re-sensitizes acute myeloid leukemia to BH3 mimetics

PMID: 42362999 | Journal: Nature cancer | Score: 8/10 Topics: T1 - Hematologic Malignancies

Inhibition of ADSS2-mediated de novo AMP biosynthesis re-sensitizes acute myeloid leukemia to BH3 mimetics.

This journal article was triaged for T1 - Hematologic Malignancies based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with limited evidence maturity.

10. Cell-free DNA dynamics and progression-free survival in metastatic gastroesophageal adenocarcinoma: insights from the REGIRI-PRODIGE 58 ancillary study

PMID: 42363005 | Journal: NPJ precision oncology | Score: 8/10 Topics: T3 - Early Cancer Detection

Cell-free DNA dynamics and progression-free survival in metastatic gastroesophageal adenocarcinoma: insights from the REGIRI-PRODIGE 58 ancillary study.

This cohort/real-world study was triaged for T3 - Early Cancer Detection based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with moderate evidence maturity.

11. Targeting CCR7-KMT2D enhances CAR-T cell efficacy by suppressing therapy-induced senescence in B-cell non-Hodgkin lymphoma

PMID: 42363110 | Journal: BMC medicine | Score: 8/10 Topics: T1 - Hematologic Malignancies

The article reports targeting CCR7-KMT2D enhances CAR-T cell efficacy by suppressing therapy-induced senescence in B-cell non-Hodgkin lymphoma.

This journal article was triaged for T1 - Hematologic Malignancies based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with moderate evidence maturity.

12. Next-generation of mesothelin-targeted CAR-T cells secreting anti-PD-L1 scFv for potent immunotherapy against 3D patient-derived colorectal cancer organoids

PMID: 42363170 | Journal: BMC medicine | Score: 8/10 Topics: T6 - Novel Therapeutics (immunotherapy/CAR-T)

The article reports next-generation of mesothelin-targeted CAR-T cells secreting anti-PD-L1 scFv for potent immunotherapy against 3D patient-derived colorectal cancer organoids.

This diagnostic/model validation study was triaged for T6 - Novel Therapeutics (immunotherapy/CAR-T) based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with moderate evidence maturity.

13. Outcomes and prognostic factors in patients with systemic mastocytosis and an associated myeloid neoplasm: an international ECNM registry study

PMID: 42363232 | Journal: Journal of hematology & oncology | Score: 8/10 Topics: T1 - Hematologic Malignancies

Outcomes and prognostic factors in patients with systemic mastocytosis and an associated myeloid neoplasm: an international ECNM registry study.

This cohort/real-world study was triaged for T1 - Hematologic Malignancies based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with moderate evidence maturity.

14. CT-based radiomics as a non-invasive virtual biopsy for high PD-L1 expression prediction in non-small cell lung cancer

PMID: 42363255 | Journal: Cancer imaging : the official publication of the International Cancer Imaging Society | Score: 8/10 Topics: T6 - Novel Therapeutics (immunotherapy/CAR-T)

The article reports cT-based radiomics as a non-invasive virtual biopsy for high PD-L1 expression prediction in non-small cell lung cancer.

This diagnostic/model validation study was triaged for T6 - Novel Therapeutics (immunotherapy/CAR-T) based on abstract review. It appears high priority because it addresses a direct clinical or diagnostic question with moderate evidence maturity.

Standard Priority Watchlist

• 7/10 42354567 - Exploratory Machine Learning-Based Classification of Type 2 Diabetes Using Routine Clinical Parameters: A Single-Center Comparative Study (Healthcare (Basel, Switzerland)).
• 7/10 42355474 - Characterization of HER2 Expression Levels, Including HER2-Ultralow, in a Retrospective Male Breast Cancer Cohort (Life (Basel, Switzerland)).
• 7/10 42355951 - Predicting Iron Deficiencies Using Routine Complete Blood Cell Count Parameters: A Machine Learning Approach and Evaluation (Journal of clinical medicine).
• 7/10 42358564 - Artificial intelligence approaches in biological age prediction: current status and challenges (British journal of biomedical science).
• 7/10 42359011 - Deciphering intratumoral microbiota in digestive system tumors: mechanisms and emerging therapeutic strategies (Frontiers in cellular and infection microbiology).
• 7/10 42361179 - Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities (Science advances).
• 7/10 42362074 - Extracellular Vesicles in Ovarian Cancer liquid Biopsy: Advances, Challenges, and Clinical Potential (Critical reviews in oncology/hematology).
• 7/10 42362634 - Using machine learning to identify individuals at elevated risk of diabetes from low-cost complete blood count data for opportunistic screening (Scientific reports).
• 7/10 42362724 - Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq (Nature biotechnology).
• 7/10 42362755 - Comparison between Pola-R-CHP and R-CHOP regimens in patients newly diagnosed with diffuse large B-cell lymphoma: a propensity score-matched study (Scientific reports).
• 7/10 42362805 - Small interfering RNA-mediated silencing of mutant NPM1 suppresses acute myeloid leukemia via reversing KAT7 and p300-mediated histone acetylation (Leukemia).
• 7/10 42363128 - Comparative assessment of the accuracy of different artificial intelligence models in answering analytical and knowledge-based questions in oral and maxillofacial radiology and oral and maxillofacial surgery; a research article (BMC oral health).
• 7/10 42363133 - Immuno-oncology in the perioperative setting: the next frontier in resectable head and neck cancers - a systematic review (BMC cancer).
• 7/10 42363217 - BTN3A1 regulate the function of Vγ9Vδ2 T cells through TCR signaling pathway in ovarian cancer (Journal of ovarian research).
• 7/10 42363321 - Red blood cell and platelet transfusion support in the first 30 days after autologous stem cell transplantation: Real-world data (JPMA. The Journal of the Pakistan Medical Association).
• 7/10 42363399 - Feasibility Study of Combined Systemic Therapy and Carbon-Ion Radiotherapy for Hepatocellular Carcinoma Patients (Cancer medicine).
• 7/10 42363493 - Metaheuristic-driven machine learning study for early detection and classification of Parkinson's disease using feature prioritization with pelican optimization algorithm (Medicine).
• 7/10 42363527 - Biomarkers of neoadjuvant immunotherapy for locally advanced head and neck cancer: A systematic review and meta-analysis (Medicine).
• 7/10 42363988 - Elucidating the pathway activity and prognostic significance of diverse regulatory cell death patterns in pancreatic ductal adenocarcinoma (Discover oncology).
• 7/10 42364024 - Opioid-sparing analgesia with clonidine versus fentanyl in inguinal hernia repair: a randomized clinical trial (Hernia : the journal of hernias and abdominal wall surgery).
• 7/10 42364040 - Deep learning classification of significant prostate cancer on MRI: a systematic review and meta-analysis (Abdominal radiology (New York)).
• 7/10 42364055 - Multi-kingdom gut microbiota analyses define bacterial-fungal interplay in multiple type 2 diabetes cohorts (Science China. Life sciences).
• 6/10 42353272 - An Immunothrombotic Extracellular Vesicle mRNA Profile Associated with Thrombosis in Lung Adenocarcinoma (International journal of molecular sciences).
• 6/10 42353345 - From Chronic Inflammation to Malignancy: Molecular Mechanisms and Therapeutic Insights in Oral Carcinogenesis (International journal of molecular sciences).
• 6/10 42358827 - Immunometabolic Reprogramming in Hepatocellular Carcinoma Mechanisms, Biomarkers, and Therapeutic Implications (Oncology research).

Topic Coverage

• T1 - Hematologic Malignancies: reviewed 20/20; HIGH 4; coverage_complete=true.
• T2 - CBC/ML Hematology: reviewed 4/4; HIGH 0; coverage_complete=true.
• T3 - Early Cancer Detection: reviewed 20/20; HIGH 4; coverage_complete=true.
• T4 - AI/ML in Clinical Diagnostics: reviewed 20/20; HIGH 0; coverage_complete=true.
• T5 - Precision Oncology/Genomic Medicine: reviewed 20/20; HIGH 1; coverage_complete=true.
• T6 - Novel Therapeutics (immunotherapy/CAR-T): reviewed 20/20; HIGH 2; coverage_complete=true.
• T7 - Cardiovascular-metabolic GLP-1/SGLT2: reviewed 20/20; HIGH 1; coverage_complete=true.
• T8 - Aging/Longevity: reviewed 20/20; HIGH 0; coverage_complete=true.
• T9 - Rare Diseases: reviewed 20/20; HIGH 2; coverage_complete=true.
• Sentinel: reviewed 10/10; HIGH 0; coverage_complete=true.

Files

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• Digest: /root/.openclaw/workspace/reports/pubmed/2026-06-27-digest.md