Dynamic monitoring of circulating tumor cells and PD-L1 combined positive score as prognostic biomarkers for adjuvant immunochemotherapy in stage III gastric cancer: A prospective observational study.

Floating cancer cells in blood predicted recurrence months before imaging in gastric cancer, offering an early warning sign for closer monitoring.

Dynamic CTC elevation during treatment preceded radiographic recurrence by a median of 284.5 days and served as an independent prognostic indicator for DFS in stage III gastric cancer; PD-L1 CPS ≥5 may better identify immunotherapy candidates than the standard CPS ≥1 threshold.

What the study was

Study design

prospective_cohort

Category

novel_therapeutics

Maturity

clinical

Journal

International Immunopharmacology

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