A programmable multi-stage microfluidic platform with micro-dam prefiltration and micro-nano hierarchical filter for synergetic capture of CTCs and SERS-based phenotype analysis.

A microfluidic device captures and categorizes circulating cancer cells with high efficiency, enabling better cancer staging and subtyping.

Programmable multi-stage microfluidic chip combining micro-dam prefiltration and micro-nano hierarchical filter achieves ~91.2% CTC capture efficiency and distinguishes epithelial (LNCaP) from mesenchymal (PC3) prostate cancer CTC subtypes using SERS nanoprobes, enabling label-based phenotypic subtyping for cancer staging.

What the study was

Study design

proof_of_concept

Category

early_cancer_detection

Maturity

emerging

Journal

Biosensors and Bioelectronics

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