Joint effects of depression, lipid metabolic dysfunction, and their trajectories on incident cardiometabolic multimorbidity: a prospective multi-cohort analysis from two national cohorts.
Depression and abnormal lipids together increase cardiometabolic disease risk far more than either alone, pointing to combined screening and prevention approaches.
Co-occurring depression and lipid metabolic dysfunction exert synergistic effects on cardiometabolic multimorbidity beyond individual risk, demonstrated in two national cohorts. Trajectory-based analysis identifies actionable high-risk subgroups for integrated prevention strategies.
What the study was
- Study design
- Prospective dual-cohort longitudinal analysis
- Population
- Middle-aged and older adults; CHARLS and ELSA national cohorts
- Category
- Prevention
- Maturity
- Validated
- Journal
- Lipids in health and disease
Why it surfaced
Two-cohort joint trajectory analysis; novel depression-lipid synergy for multimorbidity; prospective design; public health relevance.
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