The impact of T cell exhaustion in hematopoietic stem cell transplantation.
T cell exhaustion in bone marrow transplant cuts both ways—reducing graft rejection while weakening anti-leukemia effects—suggesting timed intervention strategies.
T cell exhaustion in allo-HSCT has a dual role — reducing GvHD while impairring antileukemic activity — creating a therapeutic tension that may be exploited by timed checkpoint modulation. Understanding exhaustion kinetics opens a strategy to preserve GVL while managing GvHD.
What the study was
- Study design
- Narrative review
- Population
- Allo-HSCT patients (review context)
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Stem cell research & therapy
Why it surfaced
T cell exhaustion dual GvHD/GVL role synthesis; review only; relevant for transplant immunology.
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