📅 PUBMED DAILY TRIAGE — 2026-06-29

Window: 2026-06-28T00:00:00Z → 2026-06-29T09:20:22Z (CRDT) Topics scanned: 10 | Candidates selected: 115 | Candidates reviewed: 72 High priority: 5 | Standard: 26 | Low/archive: 0 | Unsolicited finds: 0 Run status: PARTIAL_SUCCESS | Attempt: 2 of 2 Run ID: 2026-06-29-attempt2-20260629T092022Z

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

• PMID 42366424 · Safety of SGLT2 inhibitors versus DPP-4 inhibitors in super-elderly patients (≥ 80 years) · 9/10 · 🟢 NE Large propensity-matched cohort (n=65,119); mortality + multi-domain safety benefit in super-elderly T2DM; directly acti
• PMID 42366176 · Real-World Associations of KidneyIntelX Risk Stratification With Guideline-Directed Therap · 9/10 · 🟢 NE _Real-world multi-centre validation of biomarker-guided diabetic kidney disease care; large prospective cohort; directly _
• PMID 42365860 · GLP-1 receptor agonists in pediatric obesity and diabetes: a systematic review of efficacy · 9/10 · 🟢 NE Comprehensive systematic review of GLP-1 RAs in pediatric obesity/T2DM; high clinical relevance amid expanding approvals
• PMID 42366014 · Breastfeeding and risk of maternal type 2 diabetes: a prospective cohort study of 280 000 · 8/10 · 🟢 NE Massive prospective cohort (n=283,855); dose-response breastfeeding-T2DM relationship; open access BMJ Open; public heal

Early cancer detection (liquid biopsy, ctDNA, cfDNA)

• PMID 42365851 · Computer-aided detection in surveillance colonoscopy: a population-based randomized trial. · 9/10 · 🔴 EA _Largest population-based RCT (n=5,309) of AI-assisted colonoscopy in surveillance; strengthens guideline-ready evidence _

AI/ML in clinical diagnostics and imaging

• PMID 42366176 · Real-World Associations of KidneyIntelX Risk Stratification With Guideline-Directed Therap · 9/10 · 🟢 NE _Real-world multi-centre validation of biomarker-guided diabetic kidney disease care; large prospective cohort; directly _
• PMID 42365851 · Computer-aided detection in surveillance colonoscopy: a population-based randomized trial. · 9/10 · 🔴 EA _Largest population-based RCT (n=5,309) of AI-assisted colonoscopy in surveillance; strengthens guideline-ready evidence _

Aging, longevity, and population health

• PMID 42366014 · Breastfeeding and risk of maternal type 2 diabetes: a prospective cohort study of 280 000 · 8/10 · 🟢 NE Massive prospective cohort (n=283,855); dose-response breastfeeding-T2DM relationship; open access BMJ Open; public heal

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)

• No high-priority finds today (best candidate scored 7/10)

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

• No high-priority finds today (best candidate scored 6/10)

Precision oncology and genomic medicine

• No high-priority finds today (best candidate scored 7/10)

CBC-based diagnostics and machine learning in hematology

• No high-priority finds today (no articles scored ≥8; topic returned 0 results or best scored N/A)

Rare diseases with high unmet need

• No high-priority finds today (best candidate scored 5/10)

🟢⚪ STANDARD (5-7) — Top Finds by Topic

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

• PMID 42365987 · Real-World Evidence of the Effectiveness and Safety of Biosynthetic Semaglutide in Ty · 7/10 · Treatment Innovation
• PMID 42366347 · Joint effects of depression, lipid metabolic dysfunction, and their trajectories on i · 7/10 · Prevention
• PMID 42365792 · Cardiovascular-Kidney-Metabolic syndrome predicts the development of cardiovascular e · 7/10 · Diagnostics
• PMID 42366225 · Effects of synbiotic supplementation on cardiometabolic risk factors in overweight or · 6/10 · Prevention
• PMID 42366219 · The effects of Okra supplementation on blood pressure, lipid profile, and inflammatio · 5/10 · Prevention

Early cancer detection (liquid biopsy, ctDNA, cfDNA)

• PMID 42365707 · Explainable machine learning models predict liver fibrosis risk and outcome in the ge · 7/10 · Diagnostics
• PMID 42366272 · Predictive value of folate receptor-positive circulating tumor cells in postoperative · 6/10 · Early Detection

AI/ML in clinical diagnostics and imaging

• PMID 42365707 · Explainable machine learning models predict liver fibrosis risk and outcome in the ge · 7/10 · Diagnostics
• PMID 42366024 · Deep Learning-Based Automated Detection and Burden Assessment of Paramagnetic Rim Les · 6/10 · Diagnostics
• PMID 42366266 · Integrating artificial intelligence and multi-omics data for precision oncology in en · 5/10 · Genomics/Precision Medicine

Aging, longevity, and population health

• PMID 42366347 · Joint effects of depression, lipid metabolic dysfunction, and their trajectories on i · 7/10 · Prevention
• PMID 42366023 · Associations of Handgrip Strength Weakness and Asymmetry With New-Onset Stroke in Mid · 6/10 · Prevention
• PMID 42366122 · Hormone Therapy is Associated with Better Cognitive Performance in Postmenopausal Wom · 5/10 · Prevention
• PMID 42366180 · The Ageing Adipose Paradox: Implications for Metabolic Health. · 5/10 · Other
• PMID 42366121 · Association between Type 2 Diabetes and 30-Day Clinical Outcomes following Hospital D · 5/10 · Other

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)

• PMID 42366232 · Effect of magnesium supplementation on inflammatory factors and clinical outcomes of · 7/10 · Treatment Innovation
• PMID 42366150 · Masked divergence in cancer mortality following COVID-19 disruption. · 7/10 · Public Health
• PMID 42366060 · Real-world treatment outcomes of peripheral T-cell lymphoma in the era of molecular t · 7/10 · Treatment Innovation
• PMID 42366227 · Targeting BCL9/BCL9L enhances CD4(+) T cell-mediated Th1 antitumor immunity through a · 6/10 · Drug Development
• PMID 42365545 · Beyond the JAK2 mutation: The inflammasome, clonal stability, and the thrombotic nich · 5/10 · Treatment Innovation

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

• PMID 42366227 · Targeting BCL9/BCL9L enhances CD4(+) T cell-mediated Th1 antitumor immunity through a · 6/10 · Drug Development
• PMID 42366316 · Safety evaluation of TOPAZ-1 and KEYNOTE-966 regimens in metastatic biliary tract can · 6/10 · Treatment Innovation
• PMID 42366203 · Fluvoxamine combined with lenvatinib enhances anti-hepatocellular carcinoma immunity · 6/10 · Drug Development
• PMID 42365828 · Standardization of objectives and response criteria for neoadjuvant immunotherapy in · 6/10 · Treatment Innovation

Precision oncology and genomic medicine

• PMID 42366150 · Masked divergence in cancer mortality following COVID-19 disruption. · 7/10 · Public Health
• PMID 42366160 · Treatment and Survival Outcomes for Indigenous and Non-Indigenous Australians Within · 7/10 · Public Health
• PMID 42366266 · Integrating artificial intelligence and multi-omics data for precision oncology in en · 5/10 · Genomics/Precision Medicine

Rare diseases with high unmet need

• PMID 42365553 · Content validity, face validity and comprehensiveness of generic quality-of-life meas · 5/10 · Other

💡 UNSOLICITED FINDS

No unsolicited high-signal out-of-watchlist articles identified this run.

📊 TODAY'S BREAKDOWN

By research category:

• Treatment Innovation: 11
• Prevention: 6
• Diagnostics: 4
• Other: 3
• Early Detection: 2
• Public Health: 2
• Drug Development: 2
• Genomics/Precision Medicine: 1

By evidence maturity:

• Exploratory: 16
• Validated: 11
• Potentially Practice-Changing: 4

By watchlist topic (reviewed / kept / highest score):

• Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): 20 reviewed / 8 kept / highest 7/10
• CBC-based diagnostics and machine learning in hematology: 0 reviewed / 0 kept / highest N/A/10
• Early cancer detection (liquid biopsy, ctDNA, cfDNA): 4 reviewed / 4 kept / highest 9/10
• AI/ML in clinical diagnostics and imaging: 5 reviewed / 5 kept / highest 9/10
• Precision oncology and genomic medicine: 4 reviewed / 4 kept / highest 7/10
• Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 8 reviewed / 5 kept / highest 6/10
• Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 13 reviewed / 11 kept / highest 9/10
• Aging, longevity, and population health: 7 reviewed / 6 kept / highest 8/10
• Rare diseases with high unmet need: 1 reviewed / 1 kept / highest 5/10

By source type:

• peer_reviewed: 31 | preprint: 0

Topics with zero 8+ articles this run: Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma), Novel therapeutics: immunotherapy, CAR-T, targeted therapy, Precision oncology and genomic medicine, CBC-based diagnostics and machine learning in hematology, Rare diseases with high unmet need

🔧 RUN NOTES

• Run: Attempt 2 of 2. Full fresh search performed for all topics.
• Window expansion: Not triggered (≥5 articles found across topics).
• T2 (CBC/ML Hematology): Both primary and fallback queries returned 0 results for CRDT 2026-06-28 → 2026-06-29. Consistent with prior day (attempt1 also found 0). Logged.
• Truncation: T7 (Cardiovascular-metabolic) raw count 34 — cap of 20 applied. T1 (Hematology) raw 23 — cap of 20. T6 (Immunotherapy) raw 23 — cap of 20.
• Partial coverage: run_status=PARTIAL_SUCCESS because not all candidate PMIDs were reviewed with esummary in this attempt. Articles output is complete for reviewed candidates (31 articles). Unreviewed candidates from T1, T3-T8, sentinel logged in search_logs as missing_pmids.
• Scoring: v1.3 0-10 scale (novelty 0-3, relevance 0-3, design_quality 0-2, population_or_unmet_need 0-2). Non-human study cap applied. Narrative review design_quality=0.
• Schema fix: Attempt 1 failed validation due to wrong schema_version ('v1.3'), missing pipeline_handoff/phase_entry keys, incorrect score scale (0-13), wrong score_breakdown axis names, missing record_dates object. All fixed in attempt 2.