Outsmarting Antigen Escape: Next-Generation CAR T Cell Engineering Strategies for Durable Remissions.
Multiple engineering approaches to prevent CAR T cells from failing due to antigen loss are advancing toward clinical testing.
This Eur J Haematol review comprehensively covers engineering strategies that counter antigen escape in CAR T cell therapy, including bispecific/tandem CARs, logic-gated constructs, armored CAR T cells with cytokine payloads, and stem cell-like memory T cell approaches. The review provides a framework for the next generation of durable CAR T cell designs.
What the study was
- Study design
- Narrative review
- Population
- Patients with hematologic malignancies treated with CAR T cell therapy
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- European journal of haematology
Why it surfaced
Eur J Haematol review; CAR T antigen escape strategies are clinically critical given current relapse patterns; useful reference synthesis.
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