Adipokines and satiety hormones and incidence of Alzheimer's disease and dementia in older adults: a nested case-control study.
Several hormones linked to metabolism predict dementia risk independent of standard factors, revealing new intervention targets in aging.
This nested case-control study within the PREDIMED Mediterranean diet trial examined plasma adipokine and satiety hormone levels as predictors of incident Alzheimer's disease and dementia. Several cardiometabolic hormones emerged as significant predictors, linking the cardiometabolic-neurological axis to dementia risk and suggesting potential intervention targets at the metabolic-aging interface.
What the study was
- Study design
- Nested case-control study (within PREDIMED trial)
- Population
- Older adults from the PREDIMED Mediterranean diet intervention cohort
- Category
- Prevention
- Maturity
- Exploratory
- Journal
- GeroScience
Why it surfaced
GeroScience; PREDIMED sub-study; cardiometabolic hormones as dementia biomarkers; T7+T8 cross-topic; well-characterized prospective RCT cohort.
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