A meta-analysis of the long-term effects of antihypertensive therapy on the risk of major cardiovascular disease across 51 randomized trials.
Decades of data confirm blood pressure medications durably reduce heart attack and stroke risk across all major drug types and patient groups.
This Nature Medicine individual patient data meta-analysis of 51 RCTs quantifies the long-term cardiovascular benefits of antihypertensive therapy with unprecedented statistical power. The findings confirm durable risk reduction across all major drug classes, blood pressure levels, and patient subgroups, with direct global guideline implications.
What the study was
- Study design
- Individual Patient Data Meta-Analysis (51 RCTs)
- Population
- Adults with hypertension enrolled in 51 randomized controlled trials
- Category
- Prevention
- Maturity
- Potentially Practice-Changing
- Journal
- Nature medicine
Why it surfaced
Nature Medicine IPD meta-analysis of 51 RCTs (highest evidence tier); long-term antihypertensive CV benefit directly informs global clinical guidelines.
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