📅 PUBMED DAILY TRIAGE — 2026-07-02 Window: 2026-07-01T09:00:00Z → 2026-07-02T09:00:00Z (CRDT) Topics scanned: 10 (9 watchlist + 1 sentinel) | Articles reviewed: 76 candidates across topics | Candidates selected: 119 High priority: 10 | Standard: 26 | Low/archive: 0 (article array) | Unsolicited finds: 1 Run status: PARTIAL_SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Precision oncology and genomic medicine
- PMR-20260702-42385761 · Neoadjuvant toripalimab plus celecoxib vs monotherapy for dMMR/MSI-H locally advanced CRC (PICC-2 RCT) · 9/10 · Lancet Oncol RCT shows celecoxib as inexpensive COX-2 immune sensitizer improves pCR in biomarker-selected CRC — directly practice-informing.
- PMR-20260702-42384930 · Novel hidden genome classifier for small bowel adenocarcinoma (JNCI multi-institutional) · 8/10 · First systematic molecular framework for this rare GI malignancy; validated at MSK/MD Anderson/Stanford/Emory/WUSM.
- PMR-20260702-42385495 · NTRK fusion prevalence in 25,946 NSCLC patients (ETOP Lungscape) · 8/10 · Definitive prevalence estimate from largest systematic screen; directly supports TRK inhibitor patient selection criteria.
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
- PMR-20260702-42384765 · Epigenetic liquid biopsy for universal mutation-agnostic surveillance in high-risk neuroblastoma · 8/10 · Overcomes mutation-dependency barrier; pediatric rare disease; cfDNA methylation profiling works for all patients regardless of mutational background.
- PMR-20260702-42385102 · cfDNA + clinicopathologic factors for T1 CRC lymph node metastasis risk (COSMOS-CRC multicenter) · 8/10 · Directly informs endoscopic vs surgical decision-making; JCO Precision Oncology multicenter prospective study.
AI/ML in clinical diagnostics and imaging
- PMR-20260702-42386722 · Efficient deep learning framework for pathology image analysis (Nature Communications, Kather lab) · 8/10 · Solves compute barrier to clinical pathology AI deployment; multi-cohort validated in CRC and breast cancer.
- PMR-20260702-42385712 · AI-driven ASO therapeutic for progeroid laminopathies (Med journal, Gordon LB co-author) · 8/10 · AI-rare disease intersection; AI-designed antisense oligonucleotide rescues LMNA processing defects; extreme unmet need.
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
(See also 42385761 above)
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
- PMR-20260702-42387214 · Long-term antihypertensive effects on cardiovascular disease across 51 RCTs (Nature Medicine IPD meta-analysis) · 9/10 · Highest evidence tier; durable CV risk reduction confirmed across all drug classes and patient subgroups — direct global guideline input.
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
- PMR-20260702-42386710 · Zanubrutinib + R-CHOP in BTK pathway-altered previously untreated DLBCL (Phase II) · 8/10 · Supports biomarker-directed BTK inhibitor addition to frontline chemoimmunotherapy in molecularly defined subgroup.
Rare diseases with high unmet need
- PMR-20260702-42381704 · Therapeutic rescue of pathogenic asparaginyl-tRNA synthetase (NARS2) alleles (Mol Ther Nucleic Acids, PMC) · 8/10 · Proof-of-concept for suppressor tRNA + chaperone rescue of ultra-rare mitochondrial disease with no existing DMTs.
CBC-based diagnostics and machine learning in hematology
No high-priority finds today (best candidate: 0/10 — zero results on primary and fallback T2 queries for this CRDT window).
Aging, longevity, and population health
No high-priority finds today (best candidate: 7/10 — 42384796 brain asymmetry aging biomarker, Science Advances).
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies
- 42386711 · OT-55 reshapes BH3-mimetic tolerogenic apoptosis toward immunogenic cell death in AML + PD-1/Tim-3 blockade · 6/10 · Treatment Innovation
- 42386908 · PD-L2 vs PD-L1 distinct transcriptional programs in PMBL · 6/10 · Treatment Innovation
- 42387202 · Doublet post-transplant maintenance vs single-agent in MM (propensity-matched, Fred Hutch) · 6/10 · Treatment Innovation
- 42385863 · APRIL enhances BCMA CAR T via soluble BCMA inhibition (MM preclinical) · 6/10 · Treatment Innovation
- 42385640 · PCIF1/m6Am/BRD4 immunosuppression axis in MM · 5/10 · Drug Development
Early cancer detection
- 42380575 · Comprehensive urine cfDNA workflow for methylation + fragmentation (Heitzer/Deleuze) · 5/10 · Diagnostics
- 42382778 · Liquid biopsy, MCED, and AI: new frontiers review (Front Immunol, PMC) · 5/10 · Early Detection
- 42385473 · ctDNA after radical cystectomy as MRD marker in MIBC (literature review) · 4/10 · Early Detection
AI/ML in clinical diagnostics and imaging
- 42386833 · Sketch-guided multimodal fusion reduces skin tone bias in dermatology AI · 6/10 · Diagnostics (equity)
- 42385972 · ML vs conventional albumin-correction formulas for ionized calcium prediction · 5/10 · Diagnostics
- 42386861 · Deep learning on CBCT panoramic images for jaw lesion differentiation · 4/10 · Diagnostics
Precision oncology and genomic medicine
- 42386144 · Amplicon NGS panel for segmental CNV detection in WHO 2021 glioma classification (J Mol Diagn) · 7/10 · Diagnostics
- 42386186 · HER2 assessment in urothelial carcinoma: scoring pitfalls and genomic correlates (Arch Pathol) · 5/10 · Diagnostics
- 42385482 · Mitochondrial genome alterations in cancer — mutations to targeted therapies (BBRC review) · 4/10 · Genomics
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
- 42385355 · PAR1-targeted CAR T cells with microbubble enhancement for liver fibrosis (preclinical) · 6/10 · Treatment Innovation
- 42385219 · Eosinophil elevation after pembrolizumab predicts irAE in bladder cancer (multicenter) · 5/10 · Diagnostics
- 42386499 · Next-gen CAR T engineering strategies for antigen escape (Eur J Haematol review) · 4/10 · Treatment Innovation
Cardiovascular-metabolic
- 42387181 · Adipokines + satiety hormones as Alzheimer's/dementia predictors in PREDIMED nested case-control · 6/10 · Prevention
- 42387150 · Weight discrimination and cardiometabolic health in underrepresented US adults · 5/10 · Public Health
Aging, longevity, and population health
- 42384796 · Global brain asymmetry variations associate with aging and aging-related diseases (Sci Adv, Francks/Thompson) · 7/10 · Diagnostics
- 42383246 · East Asian-specific epigenetic clock for chronological age estimation (NAR Genomics, PMC) · 6/10 · Diagnostics
- 42384794 · Multimodal optical metabolic imaging illuminates aging (Science Advances) · 6/10 · Diagnostics
Rare diseases with high unmet need (new in attempt 2)
- 42381478 · Pulmonary exacerbations and treatment in PCD: narrative review (Pediatr Pulmonol) · 6/10 · Treatment Innovation (rare: Primary Ciliary Dyskinesia)
- 42380403 · Clinical and genomic characteristics of primary resistance to IO+VEGFR therapy in mRCC (Sci Rep, H-CARP+C-CAT) · 6/10 · Genomics/Precision Medicine (unmet need: PRD subgroup, 12.6% of mRCC, median OS 8.5 mo)
💡 UNSOLICITED FINDS
- 42387075 · Serum cytokine profiling distinguishes Kawasaki disease from MIS-C with coronary lesion prediction (Pediatric Research, multicenter Japan) · 5/10 · Diagnostics — cytokine signatures for clinically challenging pediatric inflammatory conditions
📊 TODAY'S BREAKDOWN
By research category:
- Treatment Innovation: 14
- Diagnostics: 12
- Early Detection: 4
- Genomics/Precision Medicine: 3
- Prevention: 2
- Drug Development: 1
- Public Health: 2
- Other: 0 (secondary only)
By evidence maturity:
- Exploratory: 18
- Validated: 17
- Potentially Practice-Changing: 1 (42387214)
By watchlist topic (reviewed / kept / highest score):
- Hematologic malignancies: 14 reviewed / 8 kept / 8
- CBC-based diagnostics (ML): 0 reviewed / 0 kept / n/a (zero results both queries)
- Early cancer detection: 10 reviewed / 6 kept / 8
- AI/ML in diagnostics: 14 reviewed / 7 kept / 8
- Precision oncology: 14 reviewed / 8 kept / 9
- Novel therapeutics: 4 reviewed / 5 kept (cross-topic) / 9
- Cardiovascular-metabolic: 7 reviewed / 4 kept / 9
- Aging/longevity: 5 reviewed / 4 kept / 7
- Rare diseases: 6 reviewed / 5 kept / 8
- Sentinel: 2 reviewed / 1 kept / 5
By source type:
- peer_reviewed: 36 | preprint: 0
Topics with zero 8+ articles this run:
- CBC-based diagnostics and machine learning in hematology (0 results, no data)
- Aging, longevity, and population health (best score: 7/10)
🔧 RUN NOTES
- PARTIAL_SUCCESS run: Topics T6 (Novel therapeutics, 4/15), T7 (CV-metabolic, 6/15), T8 (Aging, 5/15), T9 (Rare diseases, 6/9 — improved from 4/9 in attempt 1), Sentinel (2/10) had incomplete candidate coverage due to API response size constraints.
- T2 (CBC/ML hematology): 0 results on both primary and fallback queries for CRDT window 2026-07-01 to 2026-07-02. No CBC/ML hematology articles indexed in this window.
- Attempt 2 fixes: Three PMIDs that were unaccounted in attempt 1 search logs are now properly resolved:
- PMID 42385104 (Precision oncology): esummary fetched; no abstract (PubMed in-process, attributes=[]); classified title-only, scored LOW/3 (title-only cap), not in articles array.
- PMID 42381478 (Rare diseases): PCD narrative review fetched with abstract; scored STANDARD/6; added to articles.
- PMID 42380403 (Rare diseases): mRCC primary resistance retrospective cohort fetched with abstract; scored STANDARD/6; added to articles.
- Top findings: PMID 42385761 (Lancet Oncol PICC-2 RCT, celecoxib+toripalimab in MSI-H CRC, score=9); PMID 42387214 (Nat Med antihypertensive IPD meta-analysis 51 RCTs, score=9).
- Cross-topic articles: 42385761 (T5+T6); 42384765 (T3+T9); 42385712 (T4+T9); 42386711 (T1+T6); 42385863 (T1+T6); 42385219 (T6+T9); 42387181 (T7+T8).
- Excluded per policy: 42386524 (News), 42386868 (Erratum); 42386909 (Letter, title-only, score=3, not in articles); 42385104 (title-only/in-process, score=3, not in articles).
- Missing PMIDs still not fetched (39 total across topics): T1: 42386526; T4: 42386042; T5: 42384310, 42384132; T6: 42387256, 42387220, 42386672, 42386645, 42386374, 42386072, 42385856, 42385524, 42385421, 42385381, 42385353, 42385352; T7: 42387250, 42387223, 42387066, 42387065, 42387035, 42386896, 42386764, 42386709; T8: 42385130, 42385010, 42384123, 42383900, 42383390, 42382783, 42382762, 42381898, 42381472, 42381386; T9: 42386569, 42384054, 42383099, 42382843, 42382738; Sentinel: 42387250, 42387223, 42387220, 42387199, 42387182, 42387154, 42387129, 42387117.