Early detection of multiple cancers: the era of methylation-based liquid biopsy.
Reviews progress toward multi-cancer blood tests as clinical implementation nears, outlining remaining challenges for screening adoption.
Lin et al. review the landscape of DNA methylation-based multi-cancer early detection assays, summarising clinical validation milestones for Galleri, SPOT-MAS, and related technologies across large prospective cohort studies. The review contextualises key implementation challenges including tissue-of-origin prediction accuracy, specificity in asymptomatic screening populations, and clinical implementation readiness as MCED assays approach regulatory evaluation.
What the study was
- Study design
- Narrative review
- Population
- Multi-cancer early detection screening populations
- Category
- Early Detection
- Maturity
- Exploratory
- Journal
- Front Oncol
Why it surfaced
Open-access review of MCED methylation liquid biopsy directly relevant to T3 early cancer detection; PMC full text with comprehensive clinical context.
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