📅 PUBMED DAILY TRIAGE — 2026-07-03 Window: 2026-07-02T00:00:00Z → 2026-07-03T09:20:49Z (CRDT) Topics scanned: 10 | Articles reviewed: 118 | Candidates evaluated: 118 High priority: 8 | Standard: 20 | Low/archive: 0 | Unsolicited finds: 1 Run status: SUCCESS | Attempt: 2
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
- PMID-42392109 · Autologous and allogeneic HCT in adult Hodgkin lymphoma: EBMT recommendations · 9/10 · Practice guideline in Lancet Haematol; immediate standard-of-care impact for HL transplantation.
- PMID-42393054 · BRG1-mediated suppression of ferroptosis underlies BTK inhibitor resistance · 8/10 · Nature Communications mechanistic study revealing chromatin-mediated ibrutinib resistance via ferroptosis; high combination therapy potential.
AI/ML in clinical diagnostics and imaging
- PMID-42393341 · BoneCoT: multicentre validation of whole-body skeleton foundation model for bone metastases · 9/10 · Nature Biomedical Engineering; multicentre-validated AI for oncologic bone staging aligned with expert radiologists.
- PMID-42392452 · Deep Learning for Differentiating Pulmonary Metastasis from Primary Lung Cancer on Frozen Sections · 8/10 · Modern Pathology validation of intraoperative DL tool for real-time thoracic surgical decision support.
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
- PMID-42393377 · A guide to CAR T cell therapies: development, current status and future prospects · 8/10 · Nature Reviews Immunology authoritative synthesis; comprehensive roadmap for next-generation CAR T engineering.
- PMID-42392864 · USP20 promotes CD8+ T cell exhaustion and impairs KRAS G12D inhibitor efficacy · 8/10 · Gut publication; novel immune-metabolic axis to overcome KRAS G12D inhibitor resistance in PDAC.
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
- PMID-42389921 · Longitudinal ctDNA identifies patients at high risk of upstaging and recurrence in NMIBC · 8/10 · Prospective BJU International cohort; serial ctDNA outperforms standard NMIBC risk stratification.
Rare diseases with high unmet need
- PMID-42393263 · KGRD: knowledge-graph-augmented reasoning for diagnosis and counselling of paediatric rare genetic disorders · 9/10 · NPJ Digital Medicine (open access); AI framework addressing critical specialist-access deficit in paediatric rare genetics.
🟢⚪ STANDARD (5–7) — Top by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
- PMID-42393459 · Revisiting retinoic acid in AML therapy · 6/10 · Treatment Innovation
- PMID-42393270 · Impact of race on mutational profile and survival in AML (2014–2024) · 6/10 · Public Health
- PMID-42391833 · Galectin-9 and TIM-3 in CLL: role of immune evasion · 5/10 · Diagnostics
- PMID-42393108 · TG/HDL-C ratio as predictor of severe hypertriglyceridaemia in paediatric lymphoid malignancies · 5/10 · Diagnostics
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
- PMID-42392486 · Multiplex methylation marker ctDNA in anal cancer: HPV-independent approach · 7/10 · Early Detection
- PMID-42388633 · AI-enabled liquid biopsy: systematic review and meta-analysis · 7/10 · Early Detection
- PMID-42387576 · Breaking-point transition probabilities + open chromatin region features for early cancer detection · 7/10 · Early Detection
- PMID-42388617 · Early detection of multiple cancers: the era of methylation-based liquid biopsy (review) · 6/10 · Early Detection
AI/ML in clinical diagnostics and imaging
- PMID-42393483 · Deep multi-modal spatio-temporal video regression for non-invasive haemoglobin estimation · 6/10 · Diagnostics
Precision oncology and genomic medicine
- PMID-42391607 · MTB-guided osimertinib in EGFR L858R/Q701L-mutant lung adenocarcinoma · 7/10 · Genomics/Precision Medicine
- PMID-42393274 · BAX loss in neuroblastoma reveals delayed apoptosis but sustained chemotherapy sensitivity · 7/10 · Genomics/Precision Medicine
- PMID-42391786 · Importance of HPV testing in oropharyngeal cancer in two US populations · 6/10 · Diagnostics
- PMID-42391812 · PLAUR as pan-cancer prognostic biomarker and therapeutic target (multi-omics ML) · 6/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
- (No STANDARD articles; all T6 entries were HIGH this run)
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
- PMID-42392556 · Eplerenone for MINOCA: registry-based basket trial · 7/10 · Treatment Innovation
- PMID-42392577 · Appetite suppression by GLP-1 receptor agonists: role of delayed gastric emptying · 6/10 · Drug Development
- PMID-42393281 · Endomyocardial Gremlin-1 associated with remodelling and adverse outcomes in NICM · 6/10 · Diagnostics
Aging, longevity, and population health
- PMID-42390865 · Urbanicity, neighbourhood conditions, and dementia mortality · 5/10 · Public Health
Rare diseases with high unmet need
- PMID-42388640 · Alectinib for refractory ALK-positive large B-cell lymphoma (case report) · 6/10 · Treatment Innovation
- PMID-42390134 · Radiotherapy evaluation in PEComa management · 5/10 · Treatment Innovation
💡 UNSOLICITED FINDS
- PMID-42393461 · CVM-1118 Phase IIa in advanced well-differentiated neuroendocrine tumours · 7/10 · First-in-class oral anti-vasculogenic mimicry agent; Br J Cancer; clinical proof-of-concept for novel NET mechanism. (Sentinel scan, unsolicited_find=true)
📊 TODAY'S BREAKDOWN
By research category:
- Early Detection: 5 articles
- Diagnostics: 7 articles
- Treatment Innovation: 6 articles
- Drug Development: 3 articles
- Genomics/Precision Medicine: 4 articles
- Public Health: 3 articles
By evidence maturity:
- Exploratory: 18 articles
- Validated: 9 articles
- Potentially Practice-Changing: 1 article (42392109 EBMT HCT guidelines)
By pipeline priority:
- HIGH: 8 articles
- STANDARD: 20 articles
- LOW: 0 articles
By watchlist topic (reviewed / included / highest score):
- T1 Hematologic malignancies: 15 reviewed / 6 included / highest 9
- T2 CBC/ML: 0 reviewed / 0 included / highest 0 (no results in window)
- T3 Early cancer detection: 11 reviewed / 5 included / highest 8
- T4 AI/ML diagnostics: 15 reviewed / 3 included / highest 9
- T5 Precision oncology: 15 reviewed / 4 included / highest 7
- T6 Novel therapeutics: 15 reviewed / 2 included / highest 8
- T7 Cardiovascular-metabolic: 15 reviewed / 3 included / highest 7
- T8 Aging/longevity: 15 reviewed / 1 included / highest 5
- T9 Rare diseases: 7 reviewed / 3 included / highest 9
- T10 Sentinel: 10 reviewed / 1 included / highest 7
By source type: peer_reviewed: 28 | preprint: 0
Topics with zero 8+ articles this run: T5 Precision oncology, T7 Cardiovascular-metabolic, T8 Aging/longevity (best: 7, 7, 5 respectively)
🔧 RUN NOTES
- T2 CBC/ML topic returned 0 results: Both primary keyword query and relaxed fallback query returned no records indexed by CRDT on 2026-07-02/2026-07-03. No new CBC + AI/ML papers entered the CRDT window for this date. T2 coverage_complete=true by design (0 candidates = 0 to review).
- Attempt 2 corrections applied: All evidence_maturity values fixed to schema enum (Exploratory/Validated/Potentially Practice-Changing); all access_level values fixed to schema enum (Abstract only/PMC full text); species_model "preclinical" corrected to "mixed" for experimental studies using in vitro + in vivo models; all pipeline_priority values corrected (MEDIUM → STANDARD; score-5 articles LOW → STANDARD per schema rules); plain_summary field populated with exactly 2 complete sentences for every article; all required schema fields added (source_db, source_type, record_dates, publication_type, matched_watchlist_topics, unsolicited_find, research_category_primary, classification_confidence, pipeline_ready, priority_flag_code, priority_flag_label, notes).
- No window expansion triggered: 28 relevant records found across 9 active topics (≥5 threshold met).
- Partial topic coverage: T8 Aging/longevity yielded only 1 included article (JAMA Network Open dementia study, score 5); topic remains populated but at low priority this cycle.