📅 PUBMED DAILY TRIAGE — 2026-07-05 Window: 2026-07-04T00:00:00Z → 2026-07-05T23:59:59Z (CRDT) Topics scanned: 10 | Candidates evaluated: 106 High priority: 13 | Standard: 12 | Low/archive: 0 | Unsolicited finds: 1 Run status: SUCCESS Run ID: 2026-07-05-attempt3-20260705T093358Z
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Precision oncology and genomic medicine
42400003 · Multi-modal data integration reveals functionally credible predictive biomarkers in ovarian cancer · 10/10 · Top-tier Genome Med study; integrated WGS+transcriptome in 335 HGSC patients reveals 58% false-positive rate for pathoge
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42401550 · Personalized neoantigen-pulsed autologous dendritic cells in newly-diagnosed glioblastoma: a phase Ib trial · 10/10 · Phase Ib trial of personalized neoantigen DC therapy in GBM published in Nat Commun; addresses highest-unmet-need brain 42401099 · Efficacy and safety of CD19 CAR T-cell therapy in relapsed/refractory follicular lymphoma: A systematic review and meta-analysis · 9/10 · PROSPERO-registered meta-analysis of CD19 CAR-T in R/R FL showing exceptional ORR 93.5%/CRR 84.5%; high-quality evidence 42400850 · Taginostat, a new quinolone-based HDAC6 inhibitor, promotes apoptosis of chronic lymphocytic leukemia cells in vitro and in vivo by activating STAT4 · 8/10 · Novel HDAC6 inhibitor with unique STAT4/p66Shc mechanism for CLL apoptosis; primary patient cell + xenograft data; high
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
42401714 · Integrated multiclass driver ctDNA profiling enables MPNST detection and monitoring in NF1 patients · 10/10 · First integrated multi-class ctDNA assay for MPNST in NF1; AUC 0.917 in n=82 cross-validated cohort; NPJ Precision Oncol
Rare diseases with high unmet need
42401963 · Increased awareness around an ultra-rare disease can improve diagnosis delays: the French example in primary hyperoxalurias · 8/10 · National-level evidence that awareness programs reduce diagnostic delay for ultra-rare primary hyperoxaluria; published
AI/ML in clinical diagnostics and imaging
42400697 · AI-enabled clinical decision support in breast cancer care: a blinded multicenter benchmarking study comparing medically specialized with a general-purpose system · 9/10 · Rigorous blinded 7-center benchmarking showing GPT-5 outperforms FDA-cleared specialized AI-CDS in breast cancer; challe 42401625 · Precise ECG diagnosis and validation of educational utility for acute myocardial infarction using deep learning and explainable artificial intelligence · 8/10 · Deep learning ECG model for AMI with XAI educational validation; dual clinical+training utility relevant to AI in clinic
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
42401228 · Time to benefit of incretin-based therapies in adiposity-related heart failure with mildly reduced or preserved ejection fraction: a systematic review and meta-analysis · 9/10 · High-relevance meta-analysis providing time-to-benefit data for incretin therapy in HFpEF/HFmrEF — a major clinical gap; 42401410 · GLP-1 Receptor Agonist Therapy in Children and Adolescents with Obesity: A Network Meta-Analysis of Differential Cardiometabolic Efficacy and Safety Profiles · 8/10 · First network meta-analysis comparing GLP-1RAs in adolescent obesity; 17 RCTs, 1230 participants; semaglutide vs dulaglu
CBC-based diagnostics and machine learning in hematology
42400964 · Artificial neural network modelling using complete blood count for the early detection of black lung disease among Indonesian coal miners: A retrospective longitudinal study · 8/10 · CBC-based ANN for occupational lung disease early detection; n=807 longitudinal dataset; demonstrates practical utility
Aging, longevity, and population health
42401082 · Exercise-induced change in FGF21 and adiponectin and their association with metabolic syndrome in older women: a randomized controlled trial · 8/10 · RCT demonstrating exercise-induced FGF21/adiponectin increases linked to metabolic syndrome improvement in older women; 42400343 · Competing Mortality Redefines the Net Benefit of Additional Surgery After Endoscopic Resection for T1 Colorectal Cancer in Older Adults · 8/10 · Clinically impactful systematic review showing competing mortality redefines surgical benefit for early CRC in older adu
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): No high-priority finds today (best candidate scored 7/10)
🟢⚪ STANDARD (5–7) — Top by Topic
Precision oncology and genomic medicine
42401005 · Harnessing tumor-agnostic biomarkers for precision medicine in lymphoma · 7/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42401497 · Real-World Evidence of Immunotherapy Sequencing in Multiple Myeloma: Durable Responses Wit · 7/10 · Treatment Innovation 42400641 · The increased co-expression of SLC7A11 and PD-L1 was associated with poor prognosis in ext · 7/10 · Genomics/Precision Medicine 42401066 · Effect of perioperative targeted therapy duration on prognosis in patients with gastrointe · 7/10 · Treatment Innovation
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
42401800 · A primary care clinic on the frontline of early cancer detection: a retrospective observat · 7/10 · Early Detection
Rare diseases with high unmet need
42400957 · Generation of two CASK patient-derived human induced pluripotent stem cell lines to study · 7/10 · Drug Development
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
42401521 · Real-world analysis of autologous stem cell transplantation in primary central nervous sys · 7/10 · Treatment Innovation 42401412 · Epstein-Barr virus downregulates breast cancer gene 1 to facilitate GPX4-dependent ferropt · 6/10 · Drug Development 42401775 · Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Defic · 6/10 · Drug Development
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
42401896 · Synergistic SGLT2 and GLP-1R targeting alleviates systemic inflammation-induced and M1 mon · 7/10 · Drug Development 42401883 · Comparative performance of insulin resistance-related indices in predicting adverse cardio · 7/10 · Diagnostics
💡 UNSOLICITED FINDS
42401860 · Driving NCD screening at scale: outcomes of a digital, CHW-led hypertension surveillance program in rural Rwanda · 6/10 → A digital CHW-led hypertension surveillance program in rural Rwanda successfully achieved scale with measurable NCD screening outcomes, demonstrating
📊 TODAY'S BREAKDOWN
By research category: Treatment Innovation: 8 Drug Development: 5 Diagnostics: 4 Genomics/Precision Medicine: 3 Early Detection: 2 Public Health: 2 Prevention: 1
By evidence maturity: Validated: 17 Exploratory: 8
By watchlist topic (reviewed / kept / highest score): Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): 15 reviewed / 8 kept / highest 9 CBC-based diagnostics and machine learning in hematology: 1 reviewed / 1 kept / highest 8 Early cancer detection (liquid biopsy, ctDNA, cfDNA): 11 reviewed / 2 kept / highest 10 AI/ML in clinical diagnostics and imaging: 15 reviewed / 2 kept / highest 9 Precision oncology and genomic medicine: 11 reviewed / 2 kept / highest 10 Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 3 kept / highest 9 Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 5 kept / highest 9 Aging, longevity, and population health: 8 reviewed / 1 kept / highest 8 Rare diseases with high unmet need: 5 reviewed / 3 kept / highest 10 Sentinel scan: 10 reviewed / 1 kept / highest 6
By source type: peer_reviewed 25 | preprint 0
Topics with zero 8+ articles this run: Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
🔧 RUN NOTES
Attempt 3 of 3: fixed all schema validation errors from attempt 2
evidence_maturity enum corrected to Exploratory/Validated/Potentially Practice-Changing
access_level enum corrected to PMC full text/Abstract only per actual retrieval mode
classification_confidence corrected to high/medium/low string values
species_model for iPSC article (42400957) corrected from cell_line to in_vitro
sentinel_scan search_log now includes all required PMID tracking fields
T6 (Novel therapeutics) capped at 15 reviewed from 53 raw results
T7 (Cardiovascular-metabolic) capped at 15 reviewed from 32 raw results
CRDT window: 2026-07-04 to 2026-07-05
T6 (Novel therapeutics) capped at 15 candidates reviewed from 53 raw esearch results
T7 (Cardiovascular-metabolic) capped at 15 candidates reviewed from 32 raw esearch results
All 9 watchlist topics + sentinel scan completed with full PMID coverage accounting
All validator-reported errors from attempt 2 have been corrected in this attempt 3