Successful Postpartum CAR T-cell Salvage Therapy for Primary Mediastinal Large B-cell Lymphoma with Residual Disease after R-CHOP During Pregnancy.
A woman safely completed pregnancy while receiving chemotherapy for lymphoma, then achieved complete remission with immunotherapy post-delivery.
This case report describes a 29-year-old woman with primary mediastinal large B-cell lymphoma diagnosed at 19 weeks of pregnancy who received R-CHOP chemotherapy while maintaining her pregnancy, delivering a healthy infant at term. Residual disease persisted post-delivery, and subsequent CAR T-cell therapy achieved complete response, illustrating a sequential pregnancy-conscious treatment strategy for this rare scenario.
What the study was
- Study design
- case_report
- Category
- hematological oncology
- Maturity
- Exploratory
- Journal
- Internal Medicine (Tokyo, Japan)
Why it surfaced
Case report of rare clinical scenario (lymphoma diagnosed in pregnancy). Triage score capped per conservative case-report rule. Single-case evidence limits generalizability but demonstrates feasibility of sequential approach.
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