Genomic landscape of triple-negative breast cancer in South Asian populations: a systematic review.
South Asian populations show higher hereditary breast cancer susceptibility genes than documented elsewhere, highlighting need for population-specific research.
This PRISMA 2020 systematic review synthesized 8 studies reporting TNBC genomic alterations in South Asian patients from India and Pakistan, finding relatively high germline BRCA1 alteration frequencies compared to Western reference data, suggesting population-specific hereditary contribution. Evidence was too sparse for meta-analysis, but the review proposes standardized ancestry classification and HRD reporting frameworks to enable future pooled analyses in this under-represented population.
What the study was
- Study design
- systematic_review
- Category
- genomic oncology
- Maturity
- Exploratory
- Journal
- BMC Cancer
Why it surfaced
Addresses a critical genomic data gap for South Asian populations with TNBC, which has poor prognosis and limited targets. BRCA1 germline frequency differs from Western data, with implications for PARP inhibitor eligibility in an underserved population with high TNBC burden.
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