Impaired fasting glucose is comparable to diabetes mellitus in predicting mortality and cardiovascular events in patients undergoing peritoneal dialysis: the role of β-cell function and insulin resistance.
Prediabetes poses comparable cardiovascular risk to diabetes in dialysis patients, suggesting insulin resistance itself warrants aggressive management.
This retrospective cohort study in peritoneal dialysis patients found that impaired fasting glucose (IFG) was comparable to overt diabetes mellitus in predicting all-cause mortality and major adverse cardiovascular events during follow-up. HOMA-IR and markers of beta-cell dysfunction mediated this association, suggesting that insulin resistance rather than hyperglycemia per se drives cardiovascular risk in this CKD population.
What the study was
- Study design
- cohort_study
- Category
- cardiometabolic risk
- Maturity
- Validated
- Journal
- Renal Failure
Why it surfaced
Found via extended cardiometabolic search and sentinel top-10 candidates. Retrospective cohort establishing IFG as equipotent to DM for mortality/CVD prediction in peritoneal dialysis patients, with mechanistic focus on insulin resistance. New find not in attempt 1; scored conservatively STANDARD.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.