PubMed Daily Triage Digest — 2026-07-06

Run: attempt3-20260706T093508Z | Schema: v1.3 | Status: SUCCESS
Window: 2026-07-05 to 2026-07-06 (CRDT) | Topics: 10 | Articles: 21

🔴 HIGH PRIORITY (7 articles — score ≥ 8)

T1/T6 · Hematologic Malignancies / Novel Therapeutics

42402625 — Orelabrutinib (BTK inhibitor) vs chlorambucil+rituximab in 192 treatment-naïve CLL/SLL patients; HR 0.32 for PFS (p<0.0001), ORR 90.1% vs 79.2%; significantly fewer grade ≥3 AEs. First-line paradigm shift candidate. STTT

42402341 — Off-the-shelf BK-VST (virus-specific T cells) in 37 PML patients at MD Anderson; ORR 56.8%, CR 43.2%, 1-year OS 61.1% vs 0% in non-responders. No approved therapy exists for PML. Clin Infect Dis

T3 · Early Cancer Detection / ctDNA

42402363 — PRISMA SR of 52 studies synthesizing ATOMIC, DYNAMIC-III, NICHE-2 trials; dMMR → atezolizumab (3-yr DFS HR 0.50); ctDNA-guided de-escalation reduces oxaliplatin use ~60% with comparable RFS; postop ctDNA HR >5 for recurrence. Stepwise biomarker framework proposed. Cancer Invest

T6 · Novel Therapeutics

42402265 — 142 aBTC patients across 7 gemcitabine backbones + durvalumab; PFS 7.39 mo, OS 13.50 mo, ORR 33.1%; 30-min infusion non-inferior. Extends TOPAZ-1 to real-world practice. J Hepatol

42402611 — DHA (approved antimalarial) selectively degrades KRASG12D via autophagy-lysosome; restores IFN signaling; in preclinical CRCLM models potentiates regorafenib + anti-PD-1. All three agents are approved drugs. Cell Death Dis

T1 · Hematologic Malignancies (Preclinical)

42402603 — IDH3B overexpression in AML LSCs; deletion increases histone succinylation, suppresses MYC, synergizes with Revumenib (approved menin inhibitor) in KMT2A-rearranged AML in vitro + vivo. Clin Epigenetics

T7 · Cardiometabolic

42402573 — 1808 ELSA participants ≥50y; severely obese-high TyG group HR 5.06–5.12 for composite CVD; dose-response across 4 trajectory groups; supports serial TyG-composite monitoring for cardiometabolic risk stratification. Cardiovasc Diabetol

🟡 STANDARD PRIORITY (13 articles — score 4–7)

⚪ LOW PRIORITY (1 article — score ≤ 3)

Search Coverage Summary

*Combined primary + supplementary cardiovascular risk query
†Cross-topic articles (42402625, 42402661); no unsolicited watchlist-external HIGH finds

Notes

• T2 (CBC+ML): Zero hits for both primary and fallback queries in this CRDT window. No fallback expansion triggered.
• 42402705 was identified in attempt 2 via extended cardiometabolic + sentinel searches (not in attempt 1).
• 42402629 (protein lactylation): author names inferred from context; recommend manual verification.
• Sentinel scan confirmed no novel HIGH-signal watchlist-external articles in this window.
• Attempt 3 fixes from validator errors:
  • run_metadata.search_logs converted from keyed object to required array format (each entry has topic field plus full PMID coverage tracking).
  • priority_flag_code corrected for PMIDs 42402404, 42402549, 42402622: CASE_REPORT and EXPLORATORY_ONLY are not valid enum values; replaced with NONE (valid enum: EARLY_CANCER_DETECTION | NOVEL_TREATMENT | UNDERSERVED_POPULATION | NEAR_TERM_IMPLEMENTABLE | PROMISING_PRELIMINARY | NONE).