Temporal changes in cortisol secretion and their association with long-term outcomes in benign adrenal incidentalomas: a retrospective cohort study.
Long-term cortisol changes in common adrenal tumors now have clear links to heart and metabolic health outcomes, guiding personalized follow-up strategies.
This large multinational retrospective cohort study from Lancet Diabetes & Endocrinology examined how cortisol secretion evolves over time in patients with benign adrenal incidentalomas and whether these changes predict long-term cardiometabolic outcomes. The work addresses management uncertainty for the ~5% of adults with adrenal incidentalomas, where current guidelines lack evidence-based follow-up protocols for autonomous cortisol secretion.
What the study was
- Study design
- retrospective_cohort
- Population
- Adults with benign adrenal incidentalomas
- Category
- Diagnostics
- Maturity
- Validated
- Journal
- Lancet Diabetes Endocrinol
Why it surfaced
High-impact Lancet Diabetes & Endocrinology publication; large multinational cohort providing longitudinal evidence on cortisol trajectory and long-term outcomes in adrenal incidentalomas—a clinically prevalent condition with unresolved management questions linking to cardiometabolic risk.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.