📅 PUBMED DAILY TRIAGE — 2026-07-08 Window: 2026-07-07T00:00:00Z → 2026-07-08T23:59:59Z (CRDT) Topics scanned: 10 | Articles reviewed: ~137 candidates | Candidates in output: 26 High priority: 5 | Standard: 21 | Low/archive: 0 | Unsolicited finds: 1 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies
- 42413982 · Pharmacologic activity, safety, and preliminary efficacy of GEN3009, a CD37-targeting DuoH · 9/10 · First-in-human data for a first-in-class hexamerization-potentiated biparatopic CD37 antibody in B-NHL; establishes RP2D
- 42415230 · Comparison of epcoritamab, lenalidomide, and rituximab versus usual care in relapsed/refra · 9/10 · Pivotal comparative effectiveness data for FDA-approved epcoritamab+R2 vs. current standard CIT in R/R FL using patient-
CBC-based diagnostics and ML in hematology
- No high-priority finds today (best candidate scored 7/10)
Early cancer detection (liquid biopsy)
- No high-priority finds today (best candidate scored 7/10)
AI/ML in clinical diagnostics
- No high-priority finds today (best candidate scored 7/10)
Precision oncology
- 42414307 · Prognostic RNA-splicing archetypes in breast cancer identified by extended pre-training of · 8/10 · Nature Communications publication demonstrating that tumor-specialized foundation AI models can decode RNA-splicing prog
Novel therapeutics
- 42413550 · Association between Intravenous Ketamine Treatment and Cognitive Function in Patients with · 8/10 · First double-blind RCT specifically examining cognitive effects of IV ketamine in TRD—answers a critical safety/tolerabi
- 42414128 · Anti-CD19/CD22 CAR T cells in refractory immune thrombocytopenia of paediatric systemic lu · 5/10 · Extends CAR-T cell therapy into pediatric autoimmune disease (pSLE-associated refractory ITP)—a field moving rapidly fol
Cardiovascular-metabolic
- No high-priority finds today (best candidate scored 7/10)
Aging and longevity
- No high-priority finds today (best candidate scored 7/10)
Rare diseases
- No high-priority finds today (best candidate scored 7/10)
Sentinel scan
- No high-priority finds today (best candidate scored 7/10)
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies
- 42414740 · Development and validation of a radiomics nomogram for predicting outcomes follo · 7/10 · Diagnostics
- 42413234 · The clinical relevance of regional lymph node microarchitecture in oesophageal c · 7/10 · Diagnostics
- 42411692 · Evaluation of Neutrophil-Related Parameters by Hematology Analyzer for Detection · 7/10 · Diagnostics
- 42413913 · Prognostic impact of germline and somatic variants in lymphoma-associated haemop · 6/10 · Diagnostics
CBC-based diagnostics and ML in hematology
- 42411692 · Evaluation of Neutrophil-Related Parameters by Hematology Analyzer for Detection · 7/10 · Diagnostics
Early cancer detection (liquid biopsy)
- 42412782 · MOCDT: multi-cancer detection and tissue-of-origin classification via cfDNA mult · 7/10 · Early Detection
AI/ML in clinical diagnostics
- 42414740 · Development and validation of a radiomics nomogram for predicting outcomes follo · 7/10 · Diagnostics
- 42414966 · A multicenter machine learning model for predicting ICU mortality in mechanicall · 7/10 · Diagnostics
- 42414919 · MRI radiomics combined with clinical factors to predict vessels encapsulating tu · 7/10 · Diagnostics
- 42414972 · Development and multicenter validation of machine learning models for 28-day mor · 7/10 · Diagnostics
- 42412782 · MOCDT: multi-cancer detection and tissue-of-origin classification via cfDNA mult · 7/10 · Early Detection
Precision oncology
- 42413234 · The clinical relevance of regional lymph node microarchitecture in oesophageal c · 7/10 · Diagnostics
- 42415204 · CD13 identifies S100A4(+) immunosuppressive monocytes and predicts temozolomide · 7/10 · Genomics/Precision Medicine
- 42414478 · Single nucleus RNA profiling reveals potential therapeutic vulnerabilities in si · 7/10 · Genomics/Precision Medicine
- 42414919 · MRI radiomics combined with clinical factors to predict vessels encapsulating tu · 7/10 · Diagnostics
- 42414440 · Clinical utility of comprehensive genomic profiling tests using MTB management s · 6/10 · Genomics/Precision Medicine
Novel therapeutics
- 42415204 · CD13 identifies S100A4(+) immunosuppressive monocytes and predicts temozolomide · 7/10 · Genomics/Precision Medicine
- 42414478 · Single nucleus RNA profiling reveals potential therapeutic vulnerabilities in si · 7/10 · Genomics/Precision Medicine
- 42410700 · Duocarmycin-Bearing Antibody-Mimetic Drug Conjugate Combined With an ATR Inhibit · 6/10 · Drug Development
- 42411045 · Exosomal B7H3 drives immunosuppression and serves as a biomarker for PD-1 blocka · 6/10 · Diagnostics
Cardiovascular-metabolic
- 42413529 · Temporal changes in cortisol secretion and their association with long-term outc · 7/10 · Diagnostics
- 42413499 · Preventative semaglutide and tirzepatide treatment does not alter disease progre · 7/10 · Drug Development
- 42413474 · GLP-1 and MASH: When weight loss isn't the whole story. · 5/10 · Drug Development
Aging and longevity
- 42413499 · Preventative semaglutide and tirzepatide treatment does not alter disease progre · 7/10 · Drug Development
- 42411407 · Enhancing the performance and interpretability of epigenetic clocks. · 7/10 · Genomics/Precision Medicine
- 42412246 · Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial ds · 4/10 · Other
Rare diseases
- 42415093 · Cortistatin as a modulator of inflammatory and mitochondrial dysfunction in Hunt · 7/10 · Drug Development
- 42414103 · Association of dental diseases with pulmonary outcomes in a multicenter cohort o · 7/10 · Public Health
- 42413913 · Prognostic impact of germline and somatic variants in lymphoma-associated haemop · 6/10 · Diagnostics
- 42410700 · Duocarmycin-Bearing Antibody-Mimetic Drug Conjugate Combined With an ATR Inhibit · 6/10 · Drug Development
- 42411045 · Exosomal B7H3 drives immunosuppression and serves as a biomarker for PD-1 blocka · 6/10 · Diagnostics
Sentinel scan
- 42411965 · Hyperdense Capsule Sign at Noncontrast CT as an Indication for Middle Meningeal · 7/10 · Diagnostics
💡 UNSOLICITED FINDS
- 42411965 · Hyperdense Capsule Sign at Noncontrast CT as an Indication for Middle Meningeal Artery Emb · 7/10
📊 TODAY'S BREAKDOWN
- By research category: {'Treatment Innovation': 4, 'Diagnostics': 11, 'Drug Development': 4, 'Genomics/Precision Medicine': 4, 'Early Detection': 1, 'Public Health': 1, 'Other': 1}
- By evidence maturity: {'Exploratory': 23, 'Validated': 3}
- By source type: peer_reviewed 26 | preprint 0
- Topics with zero 8+ articles today: CBC-based diagnostics and ML in hematology, Early cancer detection (liquid biopsy), AI/ML in clinical diagnostics, Cardiovascular-metabolic, Aging and longevity, Rare diseases, Sentinel scan
🔧 RUN NOTES
- Attempt 3: fixed all validator-flagged enum values (evidence_maturity, access_level, species_model), pipeline_priority corrections for score<8 articles without qualifying flags, and added complete search_log PMID coverage fields.
- Sentinel scan initial query with clinical trial [pt] publication type filter returned 0 results; fallback to keyword-based broader query used.
- 3 articles (42413550, 42411965, 42414103) from prior run not found in fresh esearch; included per upsert policy with notes.