Primary Intestinal Lymphangiectasia as a cause of secondary combined immunodeficiency: case study and literature review
Rare intestinal lymphangiectasia can mimic primary immunodeficiency through protein loss, warranting consideration in unexplained immune workups.
This case report describes PIL-induced secondary combined immunodeficiency through protein-losing enteropathy in a pediatric patient, with a comprehensive literature review characterizing the immunological manifestations and management approaches. PIL is a rare disease (exact prevalence unknown) that can mimic primary immunodeficiency, and this report highlights the importance of considering PIL in workup of unexplained lymphopenia.
What the study was
- Study design
- case_report_and_literature_review
- Category
- rare_diseases
- Maturity
- Exploratory
- Journal
- Clin Immunol Commun
Why it surfaced
Rare disease educational case report with literature review; limited evidence base for clinical pipeline; useful for diagnostic awareness but no therapeutic advance or practice-changing data.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.