Urinary Gas Chromatography-Based Metabolomics for Early Detection of Liver Cirrhosis and Hepatocellular Carcinoma: A Decade of Progress
Urine metabolomics research suggests simple non-invasive detection of liver disease is possible, though large validation studies remain incomplete.
This review surveys 10 years of GC-based urine metabolomics research for non-invasive HCC and liver cirrhosis detection, noting progress from GC-MS identification of organic acid discriminators to advanced GC-TOF-MS and GC-IMS enabling trace aromatic compound detection. The TENDENCY multicenter study was designed to validate these approaches at scale but outcome data remain unpublished.
What the study was
- Study design
- narrative_review
- Category
- early_cancer_detection
- Maturity
- Exploratory
- Journal
- Biomed Chromatogr
Why it surfaced
Useful synthesis of urine metabolomics landscape for HCC detection but narrative review format without original data; TENDENCY study validation results still pending; SKIP for pipeline given review-only status.
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