Single-cell atlas reveals a Wilms tumor 1-mediated axis driving granulosa cell senescence in human ovarian aging.
Aging ovaries show a reversible molecular pathway that could become a target to slow reproductive aging.
Single-cell atlas of human ovaries identifies the WT1/p21 signaling axis as a key driver of granulosa cell senescence in ovarian aging, with NLRP3+ macrophage infiltration and IL-1β-IL-1R1 macrophage-granulosa crosstalk amplifying the senescent microenvironment in aged ovaries. The WT1/p21 axis represents a novel therapeutic target for age-related ovarian decline and female reproductive aging.
What the study was
- Study design
- single-cell transcriptomic analysis with animal and in vitro validation
- Population
- Human ovarian tissue donors (young vs. aged) and mouse models
- Category
- Genomics/Precision Medicine
- Maturity
- Exploratory
- Journal
- International journal of molecular medicine
Why it surfaced
Single-cell framework for understanding human ovarian aging; WT1/p21 axis is a novel therapeutic target for female reproductive aging and infertility; relevant to T8 aging/longevity watchlist.
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