The microbiome-gut-brain axis: a new perspective on the pathogenesis and intervention of frailty.
Microbiome changes linked to aging-related weakness suggest a potential pathway for future interventions targeting frailty.
This review presents the gut microbiome-gut-brain axis as a mechanistic framework for understanding frailty in aging, highlighting how dysbiosis promotes systemic inflammation, sarcopenia, and cognitive decline. The review is most useful as a theoretical synthesis connecting microbiome interventions to frailty endpoints, though clinical evidence for microbiome-based anti-frailty interventions remains early-stage.
What the study was
- Study design
- review
- Population
- Older adults with frailty
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Frontiers in Cellular and Infection Microbiology
Why it surfaced
Frailty is a major aging health burden with limited targeted interventions; microbiome-gut-brain axis is an emerging translational pathway; highest-quality aging article in today's scan; relevant for longevity pipeline context.
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