📅 PUBMED DAILY TRIAGE — 2026-07-12

Run ID: 2026-07-12-attempt2-20260712T091611Z
Window: 2026-07-11T00:00:00Z → 2026-07-12T23:59:59Z (CRDT)
Topics scanned: 10 | Articles reviewed: ~123 | Candidates evaluated: 123
High priority: 8 | Standard: 13 | Low/archive: 0 | Unsolicited finds: 0
Run status: PARTIAL_SUCCESS

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Early Cancer Detection

42436298 · Comprehensive clinical cancer analysis of homologous recombination deficiency biomarkers in an academic molecular profiling program · 9/10 🔴
Multi-platform HRD + ctDNA reveals >30% BRCA reversion mutation rate post-PARPi in mBC — directly actionable for platinum therapy switching.

42436159 · Detection of early-stage lung adenocarcinoma using a novel extracellular vesicle and particle-based blood test · 8/10 🔴
4-biomarker EVP proximity ligation assay: 48.5% stage I, 83.3% stage II sensitivity at 90% specificity — novel analyte class with commercial path.

Hematologic Malignancies

42434847 · QuANTUM-Wild: a Phase III, randomized trial of quizartinib in newly diagnosed FLT3-ITD-negative acute myeloid leukemia · 8/10 🟠
Phase III RCT (n≈700) for quizartinib in FLT3-neg AML — 70% of AML cases; major pipeline enrollment signal. NCT06578247.

42435781 · Dual-targeting LILRB3/LILRB4 CAR-T cells for the treatment of monocytic acute myeloid leukemia · 8/10 🟠
Bispecific LILRB3/4 CAR-T shows in vivo efficacy in monocytic AML (FAB M4/M5) xenografts while sparing normal HSPCs — first dual-target approach for this subtype.

AI/ML in Clinical Diagnostics and Imaging

42435203 · FUO-PETMamba: a PET MIP-based AI framework for aetiological classification of fever of unknown origin with multicentre validation · 8/10 🟢
AUC 0.81–0.91 across 3 independent cohorts (n=681); reader study shows junior/intermediate physician improvement — near-term clinical decision support candidate.

42436248 · Single lead electrocardiographic detection of left ventricular systolic dysfunction in pediatric and congenital heart disease · 8/10 🟢
First noise-adapted pediatric CHD ECG AI; validated in 113k+ patients across 3 centers — wearable/smartwatch monitoring pathway.

Cardiovascular-Metabolic

42436241 · Scalable risk stratification of undiagnosed heart failure using routine health data and its association with imaging phenotypes and outcomes · 8/10 🟢
FIND-HF logistic regression (AUC 0.72–0.85) validated in >18M patients across UK/Japan/USA/Taiwan — largest-scale EHR HF screening validation published.

Novel Therapeutics

42436354 · CDK8 remodels the tumor microenvironment and promotes resistance to KRAS(G12D) inhibitors and daraxonrasib in PDAC · 8/10 🟠
CDK8 as convergent resistance node for MRTX1133/daraxonrasib/zoldonrasib in PDAC (MD Anderson, multi-omic); CDK8i + αCTLA-4 restores sensitivity.

Topics with zero 8+ articles today:

• Precision Oncology: No fresh HIGH-priority finds (best: AURKA/FANCA synthetic lethality, 7/10, cross-listed from precision_oncology search)
• Aging/Longevity: No high-priority finds (best: gut microbiome-frailty review, 5/10)
• Rare Diseases: No high-priority finds (best: EHE Charité series, 5/10)
• CBC/ML Hematology: ⚠️ Zero results this CRDT window — query verified with two variants

🟢⚪ STANDARD (5–7) — Top by Topic

Precision Oncology

• 42436270 · Aurora kinase A is synthetic lethal in FANCA-deficient cancers · 7/10 · Genomics/Precision Medicine
• 42436343 · KMT2 histone methyltransferase mutations define immunotherapy-responsive esophageal adenocarcinoma subset · 7/10 · Genomics/Precision Medicine
• 42436136 · Specimen quality shapes actionable genomic landscape in CGP · 6/10 · Diagnostics

Hematologic Malignancies

• 42436094 · SOHO review: HR-MDS — VERONA missed OS; IPSS-M reclassification now essential · 7/10 · Treatment Innovation
• 42436518 · TBL1XR1 mutations impair NK cytotoxicity via MYC-CD47/PD-L1 in DLBCL · 7/10 · Treatment Innovation
• 42436123 · Second cancer risk in PV/ET: Mayo/Florence cohort · 5/10 · Public Health

Novel Therapeutics

• 42436099 · EV monotherapy, EV+pembrolizumab, ICI neoadjuvant meta-analysis for MIBC · 7/10 · Treatment Innovation

AI/ML Diagnostics

• 42436465 · Domain-specific AI outperforms GPT-4o for chest radiograph interpretation · 6/10 · Diagnostics
• 42436519 · Sphingolipid dysregulation identified as cardiometabolic HFpEF biomarker by metabolomics+ML · 6/10 · Diagnostics

Cardiovascular-Metabolic

• 42436477 · Henagliflozin reduces LV mass in T2DM+HTN (SGLT2i class signal) · 6/10 · Treatment Innovation

Rare Diseases

• 42435082 · EHE clinical characteristics at Charité Berlin (n=41; WWTR1-CAMTA1 in 67%) · 5/10 · Diagnostics
• 42434370 · Tele-dermatology for Epidermolysis Bullosa in India improves patient outreach · 5/10 · Public Health

Aging/Longevity

• 42434422 · Gut microbiome-gut-brain axis review in frailty pathogenesis · 5/10 · Treatment Innovation

💡 UNSOLICITED FINDS

None today — all high-signal finds matched at least one watchlist topic. Sentinel scan (10 candidates reviewed) overlapped entirely with watchlist topic captures.

📊 TODAY'S BREAKDOWN

By research category:

• Diagnostics: 7 articles
• Treatment Innovation: 7 articles
• Early Detection: 2 articles
• Genomics/Precision Medicine: 2 articles
• Drug Development: 1 article
• Public Health: 2 articles

By evidence maturity:

• Exploratory: 8 articles (preclinical, proof-of-concept, protocol, reviews)
• Validated: 13 articles (external validation, observational, meta-analysis, retrospective)
• Potentially Practice-Changing: 0 articles

By watchlist topic (reviewed / retained / highest score):

By source type: peer_reviewed 21 | preprint 0

Topics with zero 8+ articles this run: Precision Oncology (direct search; cross-listed HIGH articles from early_cancer_detection and novel_therapeutics counted separately), Aging/Longevity, Rare Diseases, CBC/ML Hematology, Sentinel

🔧 RUN NOTES

• Attempt 2 repair: This output was generated by repairing attempt 1 from salvage bundle. Biomedical article decisions, scores, and content are preserved from attempt 1. Schema fields normalized to v1.3.
• Pipeline priority corrections: 8 articles corrected from MEDIUM→STANDARD; 4 articles corrected from LOW→STANDARD (scores 5 fall in 4–7 STANDARD range); PMID 42436270 corrected from HIGH→STANDARD (score 7 does not meet HIGH threshold without EARLY_CANCER_DETECTION or NOVEL_TREATMENT flag).
• Enum normalizations: evidence_maturity free-text values mapped to Exploratory/Validated; access_level "open"/"subscription" mapped to "Abstract only"; classification_confidence "moderate" mapped to "medium"; species_model aliases resolved to valid enum values.
• CBC/ML Hematology: Zero CRDT results for this window — query verified with two variants. This may reflect a genuine daily gap. Monitor weekly.
• Sentinel scan: All 10 candidates reviewed; high-priority sentinel hits already captured via watchlist topic scans. No new unsolicited finds.
• PARTIAL_SUCCESS status: Reflects reconstruction from salvage rather than fresh PubMed API retrieval. PMID coverage arrays reconstructed from attempt 1 search logs.

Generated by Pulse/Friday · Run attempt 2 of 3 · 2026-07-12T09:16:11Z