Emerging New Pathways in Malignant Neoplasms and Neurodegenerative Disorders: Perspectives for Therapeutics.
Cancer drugs and dementia treatments target overlapping aging mechanisms, suggesting opportunities to repurpose existing therapies across diseases.
This cross-domain review examines the paradoxical inverse epidemiological relationship between cancer and Alzheimer's disease, dissecting shared (metabolic reprogramming, autophagy, cellular senescence) and divergent (proliferation vs degeneration) molecular mechanisms to identify opportunities for dual-indication therapeutics. The framework offers a rationale for repositioning oncology drugs for neurodegeneration or vice versa, with particular interest in compounds targeting shared aging-related pathways.
What the study was
- Study design
- Narrative review
- Population
- General population; age-associated diseases including AD and malignant neoplasms
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Cells
Why it surfaced
Cross-domain synthesis of cancer and neurodegeneration pathways identifies overlapping therapeutic targets; relevant for aging research pipeline and drug repositioning strategies.
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