Liver- and Immune-Enriched Molecular Signatures Associated With Mortality in Older Adults.
A blood test measuring 20 proteins predicts lifespan better than standard health assessments, potentially identifying high-risk older adults.
A 20-protein plasma proteomics mortality score achieves C-index 0.81 for all-cause mortality in older adults, outperforming metabolomics (0.77) and clinical risk factor models (0.73), with external validation. This record was retained from the prior triage attempt for PubMed pipeline handoff.
What the study was
- Study design
- prospective longitudinal cohort with external validation (n=848, 8.5-year follow-up)
- Category
- aging_longevity
- Maturity
- Validated
- Journal
- Aging Cell
Why it surfaced
Aging Cell publication with two-cohort validation of a proteomics-based biological aging clock superior to metabolomics and clinical models for mortality risk prediction in community-dwelling older adults.
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