Transcriptomics-driven non-invasive liquid biopsy for diagnosing peritoneal lavage cytology-positive gastric cancer.
A simple blood test measuring six genes shows strong promise for detecting aggressive gastric cancer early without invasive procedures.
A 6-mRNA liquid biopsy panel (NOX1, CHEK1, BUB1, NEK2, PRC1, SLCO1B3) achieves AUC 0.869-0.912 in peripheral blood for detecting peritoneal lavage cytology-positive gastric cancer. This record was retained from the prior triage attempt for PubMed pipeline handoff.
What the study was
- Study design
- prospective multicenter clinical study (two registered clinical trials)
- Category
- early_cancer_detection
- Maturity
- Potentially Practice-Changing
- Journal
- NPJ Precis Oncol
Why it surfaced
NPJ Precision Oncology paper validating a liquid biopsy 6-mRNA panel for a clinically difficult-to-detect gastric cancer phenotype with clear prognostic value, registered as two prospective clinical trials.
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