DNA methylation signatures distinguish extranodal NK/T-cell lymphoma and EBV-positive nodal T/NK-cell lymphoma and identify prognostic subgroups.
Different lymphoma subtypes show distinct genetic signatures that predict outcomes, enabling more precise diagnosis and prognosis.
MeDIP-seq identified fundamentally distinct epigenetic landscapes between ENKTL and nodal TNKL, and unsupervised clustering identified two prognostically distinct ENKTL subgroups differing by global methylation, TP53 status, and copy number alterations. This record was retained from the prior triage attempt for PubMed pipeline handoff.
What the study was
- Study design
- retrospective molecular study (MeDIP-seq, FFPE samples, multicenter)
- Category
- hematologic_malignancies
- Maturity
- Validated
- Journal
- Leukemia
Why it surfaced
Leukemia publication providing the first comprehensive epigenetic classification of ENKTL and nodal-TNKL using MeDIP-seq on FFPE samples, enabling refined risk stratification and therapeutic targeting for these aggressive lymphomas.
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