PubMed Triage Digest — 2026-07-18
Run ID: 2026-07-18-attempt2-20260718T091245Z
Date range: 2026-07-17 → 2026-07-18 (CRDT)
Topics scanned: 9 watchlists + sentinel
Total articles triaged: 28 (9 HIGH · 19 MEDIUM · 0 LOW included)
🔴 HIGH PRIORITY (Score 7–10)
Score 9
[PMID 42469476] Heiblig M et al. Prognostic impact of MRD in AML patients treated frontline with azacitidine and venetoclax: results from the French VENAURA registry.
Leukemia · 2026 Jul 17 · Multicenter registry cohort · Human
Topics: hematologic_malignancies
Real-world multicenter registry demonstrates that MRD negativity is a powerful independent prognostic marker after aza+ven in AML—a now-standard frontline regimen. Largest registry-based evidence to date for MRD-guided decisions in this setting.
[PMID 42469475] Topp MS, Shah BD, Jabbour E et al. Comparison of obecabtagene autoleucel versus an external control arm in adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia.
Leukemia · 2026 Jul 17 · External-controlled comparison · Human
Topics: hematologic_malignancies, novel_therapeutics
Obe-cel (obecabtagene autoleucel), a fast-process CD19 CAR-T product, showed substantially superior outcomes vs. standard salvage in r/r adult B-ALL. Obe-cel's rapid manufacturing timeline addresses a critical limitation of existing CAR-T products.
[PMID 42469167] McNerney KO, Kwon S, Naik S et al. HLH-like syndromes associate with increased risk of death and CD19-negative relapse post-CAR T in pediatric B-ALL.
Blood Adv · 2026 Jul 17 · Multicenter retrospective cohort · Human
Topics: hematologic_malignancies, novel_therapeutics
Multicenter identification of HLH-like post-CAR-T syndromes as predictors of both death and CD19-negative antigen escape in pediatric B-ALL. Urgent clinical signal for CAR-T programs: active surveillance and rapid management of HLH-like toxicity is critical.
Score 8
[PMID 42469316] Ran L, Peng Y, Wu X et al. Development and multicenter validation of an AI-driven detection system for DLBCL cells in bone marrow smears.
Sci Rep · 2026 Jul 17 · Multicenter AI validation · Human
Topics: hematologic_malignancies, ai_ml_diagnostics
AI-driven detection of DLBCL tumor cells in bone marrow smears validated across multiple centers with high accuracy. Multicenter validation crosses the key threshold separating AI proof-of-concept from clinical-translation readiness.
[PMID 42467089] Martakis K, Abreu NJ, Baker JJ et al. Neurofilament light chain (NfL) as a surrogate outcome measure for GM2 gangliosidoses.
J Neurol · 2026 Jul 17 · Multicenter observational cohort · Human
Topics: rare_diseases
Multicenter validation of NfL as a surrogate biomarker for GM2 gangliosidoses (Tay-Sachs/Sandhoff)—fatal pediatric rare diseases with no approved treatment. This biomarker validation is essential for enabling future gene therapy and enzyme replacement trials with feasible endpoints.
Score 7
[PMID 42469859] Tian Y, Geng J, Wang M et al. Plasma proteomics and machine learning deliver non-invasive distinction between fibrotic hypersensitivity pneumonitis and idiopathic pulmonary fibrosis.
J Transl Med · 2026 Jul 17 · ML biomarker discovery & validation · Human
Topics: ai_ml_diagnostics
Plasma proteomics + ML validated in independent cohort as a non-invasive blood-based test differentiating FHP from IPF. Could reduce need for surgical lung biopsy—a meaningful clinical advance for elderly/frail ILD patients.
[PMID 42468971] Rainer Q, Sun Y, Vyas M et al. Artificial Intelligence in Digital Pathology for Prostate Cancer Detection: FDA Clearance and Real-World Implementation.
J Clin Pathol · 2026 Jul 17 · Real-world implementation review · Human
Topics: ai_ml_diagnostics
First real-world implementation data for an FDA-cleared digital pathology AI for prostate cancer detection. Bridges the gap between regulatory clearance and clinical utility; provides evidence for AI-assisted pathology workflow integration.
[PMID 42469871] Ke ZY, Li J, Zhong L et al. TRIM24 stabilizes the p110 CUX1 oncoprotein via USP10 to promote chemoresistance in acute myeloid leukemia.
J Transl Med · 2026 Jul 17 · Mechanistic preclinical · Mixed (cell line + animal)
Topics: hematologic_malignancies
Novel TRIM24-USP10-CUX1 axis identified as a driver of AML chemoresistance, providing a potentially druggable target for overcoming resistance to frontline induction therapy.
[PMID 42467245] Sridhar S, Roukens G, Yu CY et al. Molecular Profiling of Tisotumab Vedotin-Treated Patients Identifies Immune Pathways Associated With Clinical Activity.
Clin Cancer Res · 2026 Jul 17 · Translational biomarker analysis · Human
Topics: precision_oncology, novel_therapeutics
Immune pathway signatures in tumors predict clinical response to tisotumab vedotin (FDA-approved ADC). Provides molecular framework for patient selection and rational combination design for this tissue factor-targeting therapy.
🟡 MEDIUM PRIORITY (Score 4–6)
| PMID | Title (abbreviated) | Source | Score | Topics |
|---|---|---|---|---|
| 42469158 | EOT PET/CT CR highly prognostic in nodal PTCL (Australasian-Canadian) | Br J Haematol | 6 | hematologic_malignancies |
| 42469044 | ML model for SLN status after NAC in early breast cancer | Acad Radiol | 6 | ai_ml_diagnostics |
| 42469640 | Explainable ML for PE prediction & classification in ED | BMC Emerg Med | 6 | ai_ml_diagnostics |
| 42467374 | Clinical outcomes of a single-center Molecular Tumor Board | Target Oncol | 6 | precision_oncology |
| 42465930 | Leukodystrophy penetrance via genomic screening + EHR (preprint) | medRxiv | 6† | rare_diseases |
| 42466426 | GenoGlyph: pan-cancer genomic inference from histopathology slides (preprint) | Res Sq | 6† | precision_oncology, ai_ml_diagnostics |
| 42468056 | ctDNA predicts VTE risk in locally advanced rectal cancer | Cancer Treat Res Commun | 5 | early_cancer_detection |
| 42467395 | ctDNA analysis in adrenocortical carcinoma | Endocr Pathol | 5 | early_cancer_detection, rare_diseases |
| 42468819 | Lung cancer screening eligibility gaps in diagnosed patients | J Am Coll Radiol | 5 | early_cancer_detection |
| 42469052 | Multimodal deep learning for thyroid cancer LN metastasis prediction | Ultrasound Med Biol | 5 | ai_ml_diagnostics |
| 42467382 | ML for septic vs. non-infectious arthritis in children (CBC-based) | Ir J Med Sci | 5 | cbc_ml_hematology, ai_ml_diagnostics |
| 42468475 | Myeloid sarcoma clinicopathological stratification (126 cases) | Leuk Res | 5 | hematologic_malignancies |
| 42468896 | Platelet-count-guided LMWH for CRT in newly diagnosed acute leukemia | Semin Thromb Hemost | 5 | hematologic_malignancies |
| 42467494 | Healthspan strategy integration into Italian NHS | Aging | 5 | aging_longevity |
| 42466621 | GM-CSF therapy in autoimmune pulmonary alveolar proteinosis (review) | Expert Opin Biol Ther | 5 | rare_diseases |
| 42464796 | AI models for rare disease diagnosis and care (commentary) | J Med Internet Res | 5 | rare_diseases, ai_ml_diagnostics |
| 42469919 | Survival in head & neck neuroendocrine carcinoma (systematic review) | Head Neck | 5 | sentinel, rare_diseases |
| 42469908 | BMI, sedentary lifestyle, HbA1c predict cardiac autonomic neuropathy | Cardiovasc Diabetol | 5 | cardiovascular_metabolic, sentinel |
| 42469626 | PCA-derived hematologic inflammatory burden score for CAD | BMC Cardiovasc Disord | 4 | cbc_ml_hematology, cardiovascular_metabolic |
| 42468153 | CHD risk & life expectancy in cancer survivors | JACC Adv | 4 | cardiovascular_metabolic |
†Preprint: score conservatively capped at 6.
Coverage Notes
| Topic | Hits | Reviewed | HIGH |
|---|---|---|---|
| hematologic_malignancies | 99 | 13 | 5 |
| cbc_ml_hematology | 2 | 2 | 0 |
| early_cancer_detection | 28 | 12 | 0 |
| ai_ml_diagnostics | 52 | 15 | 2 |
| precision_oncology | 25 | 15 | 1 |
| novel_therapeutics | 88 | 7* | 0 |
| cardiovascular_metabolic | 107 | 5* | 0 |
| aging_longevity | 30 | 5* | 0 |
| rare_diseases | 6 | 6 | 1 |
| sentinel | 1463 | 10 | 0 |
* API rate limiting (429) during initial parallel batch reduced coverage; partial batches retrieved in subsequent requests.
Generated by PubMed triage pipeline v1.3 · Run 2026-07-18-attempt2 · Friday 2026-07-18 09:12 UTC