Copper homeostasis and cuproptosis rewire the tumor microenvironment: mechanisms, immune modulation, and therapeutic opportunities.
Copper-mediated cell death could reshape the tumor microenvironment and enhance cancer immunotherapy response through a novel targeting approach.
This review in Journal of Hematology and Oncology synthesizes emerging evidence that cuproptosis - a distinct copper-mediated cell death pathway - profoundly influences the tumor microenvironment through modulation of T cell function, macrophage polarization, and cancer cell metabolic vulnerabilities. The authors propose that targeting copper homeostasis could enhance immunotherapy responses and offer a novel therapeutic dimension in precision oncology.
What the study was
- Study design
- narrative_review
- Category
- Drug Development
- Maturity
- Exploratory
- Journal
- J Hematol Oncol
Why it surfaced
J Hematol Oncol is high-impact; cuproptosis is an emerging cancer biology field with potential to complement checkpoint inhibitor therapy; review is timely and comprehensive on a rapidly growing mechanism in cancer immunology.
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