Mast cells in tumors: dual roles and therapeutic potential.
Immune cells in tumors can be redirected to fight cancer more effectively when combined with checkpoint immunotherapy.
Context-dependent mast cell activation can be both pro- and anti-tumorigenic; therapeutic targeting of mast cell polarisation represents an emerging strategy to enhance anti-tumor immunity in combination with checkpoint inhibitors. This record was retained from the prior triage attempt for PubMed pipeline handoff.
What the study was
- Study design
- narrative_review
- Category
- novel_therapeutics
- Maturity
- Exploratory
- Journal
- Cancer Immunology, Immunotherapy
Why it surfaced
Mast cell immunotherapy target review in Cancer Immunol Immunother; relevant to novel TME-based immunotherapy strategy development.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.