Pulseomic PubMed Daily Triage Digest

Run Date: 2026-07-20 | Attempt 2 | Model: claude-sonnet-4-6

Coverage Summary

• Total candidates reviewed: 57
• Total articles included: 39
• HIGH priority: 7 | STANDARD: 28 | LOW: 4
• Date window: 2026/07/19–2026/07/20 (CRDT)

Per-Topic Coverage

Note: T2 (CBC/ML Hematology) returned 0 results on this CRDT window. PMIDs 42472086, 42472160, 42472212 excluded due to metadata retrieval truncation.

HIGH Priority Articles

Efficacy and safety of HRS-7535, an oral small-molecule GLP-1 receptor agonist, in patient...

PMID: 42472282 | Score: 9/10 | Topic: Cardiovascular Metabolic | Journal: EClinicalMedicine

Key Finding: HRS-7535 90mg reduced UACR by 32% (placebo-corrected) at 16 weeks in DKD patients on intensive background therapy (SGLT2i + finerenone); HbA1c improved -1.09%, body weight -2.95%; safety consistent with GLP-1RA class; supports phase 3 renal outcome trial.

Summary: SOLID-DKD was a multicentre phase 2 RCT testing HRS-7535, a novel oral non-peptide GLP-1 receptor agonist, in 281 adults with diabetic kidney disease at 72 Chinese sites. The 90mg dose achieved a 32% placebo-corrected UACR reduction with HbA1c and weight improvements on top of standard-of-care SGLT2 inhibitor and finerenone use.

Score breakdown: novelty 3/3 · relevance 3/3 · design quality 2/2 · population/unmet need 1/2

Authors: Lv R, Peng L, Xu Y, Du X, Liu H... Access: open access | Design: randomised controlled trial | Evidence: phase 2

Multiorgan Outcomes Following BNT162b2 mRNA Vaccination vs SARS-CoV-2 Infection: A 30-Mill...

PMID: 42472854 | Score: 8/10 | Topic: Sentinel | Journal: NPJ Vaccines

Key Finding: SARS-CoV-2 infection caused 3-5x increases in acute cardiovascular events (myocarditis, mortality) persisting beyond 9 months; BNT162b2 conferred 65-76% MACE reductions; two-dose series reduced mortality by 77% vs. unvaccinated.

Summary: Using the TriNetX Research Network comprising 30.3 million individuals stratified into four immunological exposure cohorts, this study compared cardiovascular, cerebrovascular, and mortality outcomes across four time windows. SARS-CoV-2 infection conferred substantially greater and more sustained cardiovascular risk than BNT162b2 vaccination across all comparisons.

Score breakdown: novelty 2/3 · relevance 3/3 · design quality 2/2 · population/unmet need 1/2

Authors: Toraih EA, Bruce D, Hussein MH, Aiash H, Thomas SJ Access: open access | Design: retrospective cohort | Evidence: systematic evidence

Real-world outcomes of triplet therapy with gilteritinib, azacitidine and venetoclax in FM...

PMID: 42472641 | Score: 8/10 | Topic: Hematologic Malignancies | Journal: British Journal of Haematology

Key Finding: Gilteritinib + azacitidine + venetoclax triplet in FLT3+ R/R AML: ORR 100%, composite CR (mCRc) 93%; 62% bridged to allo-HSCT; 50% of transplanted patients in long-term remission at median 43-month follow-up.

Summary: This UK single-centre real-world analysis reports outcomes for FLT3-mutated relapsed/refractory AML patients receiving gilteritinib-azacitidine-venetoclax salvage triplet therapy. The regimen achieved an ORR of 100% with 93% composite CR, and among patients bridged to allogeneic HSCT, half remain in durable long-term remission.

Score breakdown: novelty 3/3 · relevance 3/3 · design quality 1/2 · population/unmet need 1/2

Authors: Chan WY, Al-Yousuf H, Lam HPJ, Leong S, Zheng J... Access: subscription | Design: retrospective cohort | Evidence: clinical observation

Hemophagocytic lymphohistiocytosis-like syndrome after CD19-directed CAR T-cells for B-cel...

PMID: 42472032 | Score: 8/10 | Topic: Hematologic Malignancies | Journal: HemaSphere

Key Finding: DESCAR-T registry (LYSA/SFCE/GRAALL) characterises HLH-like syndrome incidence, clinical presentation, and outcomes post-CD19 CAR-T in B-cell lymphoma and B-ALL; major safety signal with management implications for CAR-T programmes.

Summary: The DESCAR-T registry across three major French/European haematology groups provides the first large multicenter characterisation of HLH-like syndrome after CD19-directed CAR T-cell therapy. This registry analysis establishes the incidence, clinical course, risk factors, and outcomes of this immune toxicity, directly informing monitoring and management protocols for CAR-T programmes.

Score breakdown: novelty 2/3 · relevance 3/3 · design quality 2/2 · population/unmet need 1/2

Authors: Gower N, Houot R, Pizot C, Baruchel A, Dourthe ME... Access: open access | Design: registry study | Evidence: clinical observation

Dual-targeting pharmacological UFMylation inhibition reprograms tumor and immune microenvi...

PMID: 42472853 | Score: 7/10 | Topic: Novel Therapeutics | Journal: Signal Transduction and Targeted Therapy

Key Finding: UFMylation E3 ligase inhibition via osimertinib (novel covalent mechanism, EGFR-independent) and CP-24 achieved tumor-free outcomes in 65% of immunocompetent GBM mice with durable immune memory; mechanism: ER stress induction + macrophage M1 polarisation + PD-1 reduction.

Summary: Pharmacological inhibition of UFMylation via DDRGK1-targeting compounds including repurposed osimertinib (acting via a previously unrecognised covalent mechanism independent of EGFR) achieved tumor-free outcomes in 65% of immunocompetent GBM mice and conferred durable anti-tumor immune memory upon rechallenge. UFMylation inhibition simultaneously disrupts tumor ER homeostasis and reprograms the immune microenvironment toward anti-tumor polarisation.

Score breakdown: novelty 3/3 · relevance 3/3 · design quality 1/2 · population/unmet need 0/2

Authors: Tan P, Liu Z, Hu X, Zhang Y, Chen H... Access: open access | Design: preclinical experimental | Evidence: preclinical

Prolonged CD38 targeting with felzartamab in antibody-mediated kidney transplant rejection...

PMID: 42471965 | Score: 7/10 | Topic: Novel Therapeutics | Journal: The Lancet Regional Health – Europe

Key Finding: Felzartamab (anti-CD38) re-dosing guided by dd-cfDNA monitoring reduced microvascular inflammation to score 0 in 64% of AMR kidney transplant patients (11/11) at week 52; stable graft function; dd-cfDNA-guided dosing was feasible with variable dose requirements.

Summary: This open-label extension evaluated prolonged, biomarker-guided CD38 targeting with felzartamab in 11 kidney transplant patients with recurrent or persistent antibody-mediated rejection, using dd-cfDNA to guide dosing intervals. Sustained treatment was associated with reduced AMR activity in the majority of patients and stable graft function, supporting the concept of AMR as a chronic disease requiring ongoing immunomodulation.

Score breakdown: novelty 3/3 · relevance 3/3 · design quality 1/2 · population/unmet need 0/2

Authors: Mayer KA, Diebold M, Schrezenmeier EV, Halloran PF, Haindl S... Access: open access | Design: open label phase 2 extension | Evidence: phase 2

High-specificity gene point mutation detection by PAM-free Cas12a system with double-stran...

PMID: 42472526 | Score: 7/10 | Topic: Early Cancer Detection | Journal: Biosensors and Bioelectronics

Key Finding: PAM-free Cas12a with double-stranded substrate positioning-unwinding enables high-specificity single-nucleotide variant detection without PAM sequence constraint, expanding the detectable mutation space for liquid biopsy and somatic cancer mutation monitoring.

Summary: This study describes a PAM-free Cas12a CRISPR diagnostic platform using double-stranded substrate positioning-unwinding to achieve high-specificity single-point mutation detection without the PAM sequence limitation of conventional Cas12a systems. The approach expands the mutation detection landscape for liquid biopsy and early cancer detection, enabling sensitive identification of rare somatic variants in cell-free DNA.

Score breakdown: novelty 3/3 · relevance 3/3 · design quality 1/2 · population/unmet need 0/2

Authors: Liu Z, Wang J, Yang Z, Huang H, Zhang Z... Access: subscription | Design: experimental assay development | Evidence: preclinical

STANDARD Priority Articles

Integrative exome sequencing and multi-omics analysis elucidates the regulatory role ...

PMID: 42472903 | Score: 6/10 | Topic: Cardiovascular Metabolic | Journal: Functional and Integrative Genomics

Key Finding: Integrative exome sequencing with multi-omics reveals rare variant contributions to metabolic syndrome pathogenesis, identifying regulatory mechanisms and novel gene candidates as biomarkers or therapeutic targets for cardiometabolic precision medicine.

Authors: Wu CX, Sang J, Xu Q...

SLC25A51 and mitochondrial NAD+ transport in acute myeloid leukemia: mechanisms, ther...

PMID: 42472419 | Score: 6/10 | Topic: Hematologic Malignancies | Journal: Human Cell

Key Finding: SLC25A51-mediated mitochondrial NAD+ transport is a novel metabolic vulnerability in AML with therapeutic targeting potential; mitochondrial metabolic rewiring represents an alternative approach to standard cytotoxic therapy resistance.

Authors: Rong C, Chen R, Lou H...

A diffusion-conditioned representation learning framework for disease classification ...

PMID: 42472839 | Score: 6/10 | Topic: Ai Diagnostics | Journal: BMC Research Notes

Key Finding: Diffusion model-conditioned representation learning improves disease classification in medical imaging versus standard supervised approaches, offering a data-efficient AI framework applicable to rare disease and pathology imaging contexts.

Authors: Borah J, Saini R, Fayjie AR...

Pretreatment stromal CD4+ T-cell density predicts favorable response to total neoadju...

PMID: 42472348 | Score: 6/10 | Topic: Precision Oncology | Journal: Biomolecules and Biomedicine

Key Finding: Higher pretreatment stromal CD4+ T-cell density significantly predicts pathological response to total neoadjuvant therapy in locally advanced rectal cancer, supporting its utility as an accessible tissue biomarker for treatment stratification.

Authors: Telci H, Goktas Aydin S, Erkinuresin T...

Impact of Dapagliflozin (Sodium-glucose Transport Protein 2 Inhibitor) on Liver Steat...

PMID: 42471767 | Score: 6/10 | Topic: Cardiovascular Metabolic | Journal: Annals of African Medicine

Key Finding: Dapagliflozin treatment in T2DM+MASLD patients was associated with significant reductions in liver steatosis and fibrosis markers, supporting SGLT2 inhibitor hepatoprotective benefits in cardiometabolic comorbidity.

Authors: Ayaz S, Husaini SHM, Ashraf H...

The role of serologic biomarkers "liquid biopsy" in the fight against breast cancer: ...

PMID: 42472109 | Score: 5/10 | Topic: Early Cancer Detection | Journal: iScience

Key Finding: Serologic liquid biopsy biomarkers (ctDNA, cfDNA, exosomes, CTCs, protein markers) span from discovery to clinical implementation in breast cancer, with current gaps in standardisation and prospective validation limiting routine adoption.

Authors: Li Y, Wang Y, Wang R...

Risk and Survival Outcomes of Secondary Primary Malignancies in Chinese Lymphoma Pati...

PMID: 42472029 | Score: 5/10 | Topic: Hematologic Malignancies | Journal: Blood and Lymphatic Cancer: Targets and Therapy

Key Finding: Lymphoma patients treated in the modern targeted therapy era carry a quantifiable secondary primary malignancy risk with characterised survival impacts, informing long-term survivorship surveillance protocols.

Authors: Qiu C, Zhang T, Yang X...

PET/CT in Lymphomas: Current clinical applications and future directions....

PMID: 42472323 | Score: 5/10 | Topic: Hematologic Malignancies | Journal: Hellenic Journal of Nuclear Medicine

Key Finding: PET/CT is the standard of care for staging, response assessment, and surveillance in lymphoma; emerging applications include minimal residual disease detection, liquid biopsy integration, and AI-based radiomics for personalised treatment adaptation.

Authors: Paschali A, Iakovoglou D, Kalathas T...

The ferroptosis-related LncRNA CASC9 reveals its potential as a diagnostic and progno...

PMID: 42472876 | Score: 5/10 | Topic: Sentinel | Journal: Scientific Reports

Key Finding: LncRNA CASC9 is associated with ferroptosis pathways and demonstrates diagnostic and prognostic utility in esophageal squamous cell carcinoma, providing a novel candidate biomarker for a cancer with poor prognosis and limited early detection tools.

Authors: Yaoyao W, Qingfeng L, Liyou H...

Comparative review of contemporary guidelines for differentiated thyroid cancer manag...

PMID: 42472331 | Score: 5/10 | Topic: Precision Oncology | Journal: Hellenic Journal of Nuclear Medicine

Key Finding: Comparative analysis of ATA, ETA, and ESMO guidelines for differentiated thyroid cancer reveals key areas of consensus and divergence in risk stratification, radioiodine utilisation, and surveillance, enabling evidence-based clinical decision-making.

Authors: Charalambous P, Gourgiotis S, Giannoula E

From uncertainty to clarity: The evolution of Nuclear Medicine towards precision ther...

PMID: 42472318 | Score: 5/10 | Topic: Ai Diagnostics | Journal: Hellenic Journal of Nuclear Medicine

Key Finding: AI-driven digital twin frameworks in nuclear medicine enable patient-specific dosimetry modelling and personalised theranostic treatment planning, representing a paradigm shift toward precision theranostics for cancer.

Authors: Giammarile F, Paez D, Brink A...

Exosomes in cancer drug resistance: dual roles in therapy failure and emerging precis...

PMID: 42472816 | Score: 5/10 | Topic: Precision Oncology | Journal: Cancer Cell International

Key Finding: Exosomes mediate cancer drug resistance via intercellular transfer of resistance factors and TME modulation, while also offering a precision drug delivery vehicle platform potentially capable of reversing resistance.

Authors: Tegegne BA, Belew H, Teffera ZH...

Predictive value of systemic inflammatory indices in metabolic syndrome and non-alcoh...

PMID: 42472984 | Score: 5/10 | Topic: Cardiovascular Metabolic | Journal: Scientific Reports

Key Finding: CBC-derived systemic inflammatory indices (SII, NLR, PLR) demonstrate significant predictive value for metabolic syndrome and NAFLD, providing accessible, low-cost cardiometabolic risk biomarkers with broad clinical applicability.

Authors: Neamatshahi M, Keykhosravi A, Erdizi MJ...

An evidence informed framework for artificial intelligence in rare breast cancers usi...

PMID: 42472394 | Score: 5/10 | Topic: Ai Diagnostics | Journal: Discover Oncology

Key Finding: A governance framework for AI in rare breast cancers proposes synthetic data augmentation and small-cohort validation strategies to address data scarcity, enabling responsible AI clinical deployment in rare disease oncology.

Authors: Alshreef BS

COPD is associated with poorer survival in patients with advanced non-small cell lung...

PMID: 42472803 | Score: 5/10 | Topic: Novel Therapeutics | Journal: BMC Pulmonary Medicine

Key Finding: Comorbid COPD is an independent negative prognostic factor for survival in advanced NSCLC receiving first-line ICI + chemotherapy, supporting COPD as a key patient stratification variable for ICI-based regimens.

Authors: Takano A, Shibahara D, Ogata H...

Hypertension among people living with HIV (PLHIV) compared with people without HIV (P...

PMID: 42472664 | Score: 5/10 | Topic: Cardiovascular Metabolic | Journal: HIV Medicine

Key Finding: PLHIV have significantly elevated hypertension prevalence versus HIV-negative controls in meta-analysis, establishing HIV as an independent cardiometabolic risk factor requiring integrated cardiovascular management in HIV care.

Authors: Gomes MG, Cunha KS, Parreira ECA...

Genetic epidemiological pipeline identifies candidate markers of clozapine-induced me...

PMID: 42472444 | Score: 5/10 | Topic: Cardiovascular Metabolic | Journal: The World Journal of Biological Psychiatry

Key Finding: Genetic epidemiological pipeline identifies candidate genomic markers for clozapine-induced metabolic dysfunction, enabling precision prescribing strategies to reduce cardiometabolic toxicity in treatment-resistant schizophrenia.

Authors: Shepherd R, Suppiah V, Mulugeta A...

Extending the global landscape of Bruck syndrome: Case series of Indonesian and Ukrai...

PMID: 42471862 | Score: 5/10 | Topic: Rare Diseases | Journal: Bone Reports

Key Finding: PLOD2-variant Bruck syndrome documented in Indonesian and Ukrainian patients expands the global geographic and mutational landscape of this ultra-rare bone fragility syndrome, supporting international epidemiological characterisation efforts.

Authors: Paveta DA, Utari A, Cayami FK...

Optimising Radiologist Performance in Cancer Detection on Mammograms: The Impact of W...

PMID: 42472897 | Score: 5/10 | Topic: Sentinel | Journal: Journal of Cancer Education

Key Finding: Weekly mammogram reading volume and dedicated BreastScreen programme experience independently predict radiologist cancer detection performance, providing evidence for minimum volume requirements and specialist training standards.

Authors: Wells J, Trieu PDY, Barron ML...

Diagnostic accuracy of the COMPASS-31 orthostatic intolerance domain for detecting ca...

PMID: 42472830 | Score: 5/10 | Topic: Sentinel | Journal: Cardiovascular Diabetology – Endocrinology Reports

Key Finding: The COMPASS-31 orthostatic intolerance domain demonstrates adequate diagnostic accuracy for cardiovascular autonomic neuropathy detection in resource-limited settings, providing a validated low-cost questionnaire-based screening tool.

Authors: Haji HT, Ali RM, Khamis AG...

Cardiovascular risk assessment in oncologic patients. A narrative review....

PMID: 42472321 | Score: 4/10 | Topic: Cardiovascular Metabolic | Journal: Hellenic Journal of Nuclear Medicine

Key Finding: Oncology patients require systematic cardiovascular risk assessment integrating cancer-associated risk factors, treatment cardiotoxicity, and comorbidities within an integrated cardio-oncology framework.

Authors: Lafaras CT, Lafara KC, Mandala EM

Proteomic characterization of airway obstruction-associated proteins in non-smoking l...

PMID: 42472420 | Score: 4/10 | Topic: Precision Oncology | Journal: Clinical and Translational Oncology

Key Finding: Proteomic profiling identifies airway obstruction-associated proteins in non-smoking lung adenocarcinoma, revealing molecular mechanisms linking COPD-like physiology to NSCLC pathogenesis in never-smokers.

Authors: Jiang S, Xu Q, Liu D...

Mast cells in tumors: dual roles and therapeutic potential....

PMID: 42472716 | Score: 4/10 | Topic: Novel Therapeutics | Journal: Cancer Immunology, Immunotherapy

Key Finding: Context-dependent mast cell activation can be both pro- and anti-tumorigenic; therapeutic targeting of mast cell polarisation represents an emerging strategy to enhance anti-tumor immunity in combination with checkpoint inhibitors.

Authors: Song D, Yan G, Zhang G

ncRNA-driven regulation of PD-L1 in breast cancer: mechanisms of immune escape and th...

PMID: 42472410 | Score: 4/10 | Topic: Novel Therapeutics | Journal: Clinical and Experimental Medicine

Key Finding: lncRNAs, miRNAs, and circRNAs regulate PD-L1 expression in breast cancer through diverse transcriptional and post-transcriptional mechanisms, revealing novel ncRNA-based targets to overcome checkpoint therapy resistance.

Authors: Mardi A, Moghaddam SR, Motlagh AR...

Real-world diagnostic and management decisions in rhinology by a large language model...

PMID: 42472948 | Score: 4/10 | Topic: Ai Diagnostics | Journal: European Archives of Oto-Rhino-Laryngology

Key Finding: LLM-generated diagnostic and management decisions in rhinology show concordance with clinical practice in a real-world retrospective evaluation, demonstrating AI-assisted clinical decision support feasibility in specialty ENT settings.

Authors: Alanazi NF, Aldawood TA, Alfayez A...

The peak distress thermometer as a potent prognostic indicator for five-year survival...

PMID: 42472947 | Score: 4/10 | Topic: Sentinel | Journal: European Archives of Oto-Rhino-Laryngology

Key Finding: Peak distress thermometer score at diagnosis is an independent prognostic factor for 5-year survival in hypopharyngeal cancer, providing a simple patient-reported outcome tool with prognostic utility in a high-mortality cancer.

Authors: Hsu CM

Diagnostic accuracy of imaging in facial nerve tumors....

PMID: 42472932 | Score: 4/10 | Topic: Sentinel | Journal: European Archives of Oto-Rhino-Laryngology

Key Finding: Imaging modalities demonstrate defined diagnostic accuracy profiles for facial nerve tumors, with specific sensitivities and specificities characterised to guide pre-surgical workup and differential diagnosis.

Authors: Morales-Puebla JM, Ruano de Pablo L, Varo Alonso M...

Identification of Potential Core Genes in Medication-Related Osteonecrosis of the Jaw...

PMID: 42473030 | Score: 4/10 | Topic: Sentinel | Journal: Oral Diseases

Key Finding: Bioinformatics analysis identifies candidate core genes involved in medication-related osteonecrosis of the jaw (MRONJ), providing mechanistic insights and potential therapeutic targets for this treatment-limiting toxicity.

Authors: Duan X, Bian Y, Han S...

LOW Priority Articles

• PMID 42472063 (score 3) [hematologic malignancies] — Impressive Skin and Systemic Response Despite Patient Underestimation and Delaye...
• PMID 42471957 (score 3) [hematologic malignancies] — Pyrogallol inhibits T cell lymphoma growth by mediating G2/M phase cell cycle ar...
• PMID 42471993 (score 3) [aging longevity] — Regulation of Mitochondrial Homeostasis: Applications of Nanobiomaterials in Age...
• PMID 42471753 (score 3) [aging longevity] — The design of embedded pragmatic clinical trials: methodological developments an...

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