Gut microbiome profiles as predictors of response to chemoradiotherapy in locally advanced rectal cancer
Gut bacteria profiles before cancer treatment predict who responds well, potentially enabling personalized therapy planning.
This prospective cohort study demonstrates that pre-treatment gut microbiome composition can predict chemoradiotherapy response in locally advanced rectal cancer, with specific bacterial signatures distinguishing complete responders from non-responders. The findings suggest gut microbiome profiling may serve as a non-invasive predictive biomarker to personalize neoadjuvant treatment in rectal cancer.
What the study was
- Study design
- Prospective cohort study
- Population
- Patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy
- Category
- Genomics/Precision Medicine
- Maturity
- Exploratory
- Journal
- Acta microbiologica et immunologica Hungarica
Why it surfaced
Prospective microbiome-based prediction study for rectal cancer CRT response; emerging non-invasive precision biomarker for treatment personalization.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.