Neurotransmitter-Defined Degeneration Patterns in Sporadic and C9orf72-Associated Amyotrophic Lateral Sclerosis
Brain imaging reveals subtype-specific neurodegeneration patterns in ALS, pointing toward genetic-based precision treatments.
This Annals of Neurology study identifies neurotransmitter system-specific neurodegeneration patterns that distinguish sporadic from C9orf72-associated ALS using multimodal neuroimaging, providing mechanistic evidence for disease subtype heterogeneity. Findings support the development of genotype-stratified precision treatments in ALS and identify novel neurotransmitter system targets.
What the study was
- Study design
- Prospective neuroimaging cohort study
- Population
- ALS patients (sporadic and C9orf72-associated) with multimodal neuroimaging
- Category
- Diagnostics
- Maturity
- Exploratory
- Journal
- Annals of neurology
Why it surfaced
Annals of Neurology study defining ALS heterogeneity via neurotransmitter signatures; ALS is high-unmet-need with very few effective therapies.
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