📅 PUBMED DAILY TRIAGE — 2026-07-22 Window: 2026-07-21T00:00:00Z → 2026-07-22T23:59:59Z (CRDT) [T3 expanded to 48h: 2026-07-20 → 2026-07-22] Topics scanned: 9 watchlist + 1 sentinel | Candidates reviewed: 112 High priority: 10 | Standard: 30 | Low/archive: 0 | Unsolicited finds: 2 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
No high-priority finds today (best candidate scored 7/10)
CBC-based diagnostics and machine learning in hematology
No results found in CRDT window (zero esearch results on primary and fallback queries)
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
42476725 · Phase 1/2 study of IMC-C103C, a T cell receptor bispecific (MAGE-A4xCD3) ImmTAC targeting ... · 9/10 · First-in-human Phase 1/2 of a novel ImmTAC bispecific (MAGE-A4xCD3) in refractory solid tumors; addresses major unmet ne 42477403 · Circulating epigenetic and epitranscriptomic biomarkers identify EGFR status, predict TKI ... · 8/10 · Novel epigenetic/epitranscriptomic cfDNA layer for EGFR identification and TKI response prediction in NSCLC; first evide 42475778 · Accelerating Lung Cancer Management Through Previsit Liquid Biopsy: Results From the LUNG-... · 8/10 · Prospective LUNG-MAP study demonstrating previsit liquid biopsy reduces treatment delays in NSCLC; directly implementabl 42475517 · Clinical Utility of Next Generation Sequencing in Concurrent EBUS-TBNA and Liquid Biopsies... · 8/10 · Prospective 199-patient AJRCCM study comparing tissue vs. liquid biopsy NGS yields; provides clinically actionable evide
AI/ML in clinical diagnostics and imaging
42479708 · Feature integration of [18F]FDG PET brain imaging using deep learning for sensitive cognit... · 8/10 · DL model for early Alzheimer's/cognitive decline detection from FDG-PET addresses a large unmet clinical need with a dir
Precision oncology and genomic medicine
42477876 · Design-Outcome Concordance in Targeted-Therapy Trials in Non-Small Cell Lung Cancer: A Met... · 8/10 · JNCI meta-analysis on NSCLC targeted therapy trial design concordance; informs precision oncology evidence quality inter
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42479432 · Troponin Screening and Major Cardiovascular Adverse Events During Immune Checkpoint Inhibi... · 9/10 · JAMA Network Open multicenter study validating troponin cardiac surveillance during ICI therapy; directly actionable for
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
42479992 · Central Obesity and Recurrent Cardiovascular Events in Patients With Obstructive Sleep Apn... · 9/10 · RCT-level evidence in Neurology linking central obesity to CV recurrence in OSA; large cardiometabolic population with d
Aging, longevity, and population health
42479998 · Senescence Gene Expression Profiles and 90-Day Outcome in Stroke Patients · 9/10 · Novel senescence transcriptomic biomarker for stroke outcome in Neurology; bridges aging biology and acute neurology wit 42479178 · Cerebral amyloid angiopathy, brain iron concentrations, and cognitive decline in older peo... · 8/10 · Acta Neuropathologica study linking CAA to brain iron dysregulation as synergistic driver of cognitive decline; novel me
Rare diseases with high unmet need
No high-priority finds today (best candidate scored 6/10)
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
42479904 · Clinical Impact of BTK Inhibitor Exposure in LymphGen-Defined MCD Diffuse Large ... · 7/10 · Treatment Innovation 42478712 · The Nicotinamide Salvage Pathway is a Metabolic Vulnerability of High-Risk MDS S... · 7/10 · Drug Development 42478578 · Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anapla... · 6/10 · Genomics/Precision Medicine 42478550 · TP53 Amplification, a Rare but Recurrent Alteration in Myeloid Neoplasms · 6/10 · Genomics/Precision Medicine 42479645 · Practical Guide for Managing Philadelphia-Negative Myeloproliferative Neoplasms ... · 5/10 · Treatment Innovation
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
42479643 · Dynamic Changes in Circulating and Tissue Biomarkers and Therapeutic Response to... · 7/10 · Diagnostics 42479142 · Interference of Clonal Hematopoiesis in cfDNA Liquid Biopsy Testing and Identifi... · 7/10 · Diagnostics 42477937 · Advancement of subtype-based early breast cancer systematic therapy · 5/10 · Treatment Innovation
AI/ML in clinical diagnostics and imaging
42480126 · UMCA-Net: Uncertainty-aware Multi-stage Cross-Attention for Cost-aware Multi-omi... · 6/10 · Diagnostics 42480093 · Enhancing Efficiency and Improving Turnaround Time: Real-World Impact of the Gen... · 6/10 · Diagnostics 42479508 · Individual-Specific Functional Connectivity-Based State Classification and Progn... · 6/10 · Diagnostics 42479054 · AI-assisted TURP slide review: a multi-reader study of efficiency, diagnostic pe... · 6/10 · Diagnostics 42479342 · A Deep Learning AI Model for Histopathological Diagnosis and Grading of Mucoepid... · 5/10 · Diagnostics
Precision oncology and genomic medicine
42477931 · Analysis of homologous recombination deficiency testing in ovarian cancer based ... · 7/10 · Genomics/Precision Medicine 42479457 · Gut microbiome profiles as predictors of response to chemoradiotherapy in locall... · 6/10 · Genomics/Precision Medicine 42478154 · An Integrative Methylation-Metabolism Gene Signature Defines Prognosis and Immun... · 6/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42479906 · Neurotransmitter-Defined Degeneration Patterns in Sporadic and C9orf72-Associate... · 6/10 · Diagnostics 42479884 · Cystine Restriction Alleviates T Cell Exhaustion and Enhances CAR-T Cell Potency · 5/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
42480049 · Effects of Remote, Virtual, or Hybrid Cardiac Rehabilitation Supported by mHealt... · 7/10 · Prevention 42479756 · Effectiveness of a Culturally Adapted Group-Based Lifestyle Intervention in Redu... · 7/10 · Prevention 42480114 · The Predictive Value of the TAPSE/PASP Ratio for Major Adverse Cardiovascular Ev... · 6/10 · Diagnostics 42479931 · Comparative Risks of Cerebrovascular and Heart Disease in Women with Infertility... · 6/10 · Public Health 42479683 · Causal Associations and Potential Mediating Factors Between Sarcopenia-related T... · 6/10 · Public Health
Aging, longevity, and population health
42479667 · Brain aging patterns among nine neurological disorders: A case-control study · 7/10 · Diagnostics 42478385 · Burden of Mild Cognitive Impairment among the Elderly in India: A Systematic Rev... · 7/10 · Public Health 42479734 · Bidirectional Association Between Cognitive Function and Depressive Symptoms Med... · 6/10 · Prevention 42479932 · Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights · 5/10 · Other
Rare diseases with high unmet need
42477762 · Pathological subtype dictates survival and failure pattern in laryngeal neuroend... · 6/10 · Treatment Innovation
💡 UNSOLICITED FINDS
42480100 · Using Co-Designed Norm-Based Nudges to Promote Mental Health Help-Seeking Intentions ... · 6/10 A co-designed RCT protocol tests whether norm-based behavioral nudges tailored to older adults improve mental health ser
42480168 · Determinants and Promotion Strategies for Type 1 Diabetes Screening in Children: A Qu... · 4/10 Key determinants of T1D screening uptake in at-risk children include family awareness, provider recommendation patterns,
📊 TODAY'S BREAKDOWN
By research category:
- Diagnostics: 15
- Treatment Innovation: 7
- Genomics/Precision Medicine: 6
- Prevention: 5
- Public Health: 3
- Other: 2
- Drug Development: 1
- Mental Health: 1
By evidence maturity:
- Exploratory: 27
- Validated: 13
By source type:
- peer_reviewed: 40
By watchlist topic (reviewed / retained / highest score):
- Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): 15 reviewed / 5 retained / highest 7/10
- CBC-based diagnostics and machine learning in hematology: 0 reviewed / 0 retained / highest 0/10
- Early cancer detection (liquid biopsy, ctDNA, cfDNA): 15 reviewed / 7 retained / highest 9/10
- AI/ML in clinical diagnostics and imaging: 15 reviewed / 6 retained / highest 8/10
- Precision oncology and genomic medicine: 9 reviewed / 5 retained / highest 8/10
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 4 retained / highest 9/10
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 7 retained / highest 9/10
- Aging, longevity, and population health: 15 reviewed / 6 retained / highest 9/10
- Rare diseases with high unmet need: 1 reviewed / 1 retained / highest 6/10
Topics with zero 8+ articles this run:
- Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
- CBC-based diagnostics and machine learning in hematology
- Rare diseases with high unmet need
🔧 RUN NOTES
- Window expansion triggered for T3 (Early cancer detection): Only 4 results in 24h CRDT window; expanded to 48h (2026-07-20 to 2026-07-22) per run rules; expanded to 20 candidates, 15 selected.
- T2 (CBC/ML Hematology) zero results: Both primary query (with prediction/classification terms) and fallback query (core CBC/ML terms only) returned 0 results for the 2026-07-21/22 CRDT window. No new PubMed-indexed CBC/ML articles entered the system during this period.
- T9 (Rare diseases) sparse: Only 1 result in the CRDT window; retained for pipeline coverage.
- Sentinel overlap: PMIDs 42480135, 42480126, 42480114 already captured by watchlist topics T4 and T7; not separately emitted as unsolicited finds.
- Abstract coverage: 98 of 102 unique PMIDs had full abstracts via efetch XML; 4 records (2 Letters in T1: 42479953, 42479949; 1 editorial in T6: 42479497; 1 T7 article: 42479608) had no abstract; these were scored from title/metadata only with conservative caps applied.
- No truncation: All topics were fully reviewed up to the 15-candidate cap; T2 was the only topic with zero results.
- Run attempt: Attempt 1 of 3; run_status=SUCCESS; all topics with available results were fully covered.