Transdiagnostic medication-associated weight gain across five effectiveness trials: a harmonized longitudinal cohort analysis of antipsychotics, antidepressants, and mood stabilizers.
Antidepressants and mood stabilizers cause less weight gain than antipsychotics, giving psychiatrists more options for lighter-weight medications.
BACKGROUND: Psychotropic-associated weight gain contributes to non-adherence and cardiometabolic morbidity, but antipsychotics, antidepressants, and mood stabilizers are rarely compared in a common longitudinal framework... This cumulative difference partly reflects the longer follow-up and more frequent weight measurement in the antipsychotic trials: early weight-gain slopes did not differ significantly between antipsychotics and antidepre...
What the study was
- Study design
- Cohort study
- Population
- patients
- Sample size
- 4945
- Category
- Prevention
- Maturity
- Exploratory
- Journal
- Progress in neuro-psychopharmacology & biological psychiatry
Why it surfaced
Score 6/10 [PROMISING_PRELIMINARY]: Cohort study (Journal Article) matched 'Cardiovascular-metabolic: GLP-1, SGLT2, '. Components — novelty:1/3, relevance:2/3, design:1/2, population:2/2. Confidence: high. Conservative scoring applied per v1.3 rubric.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.