A sex-specific perspective on coronary microvascular dysfunction in HFpEF: from vascular to myocardial disease.
Sex-specific coronary dysfunction contributes to heart failure in women, pointing toward need for sex-informed diagnostic and treatment approaches.
Heart failure with preserved ejection fraction (HFpEF) is the most prevalent form of heart failure and is characterized by high morbidity, limited therapeutic options, and marked biological heterogeneity. Impaired coronary flow reserve, endothelial dysfunction, reduced nitric oxide bioavailability, and microvascular rarefaction contribute to myocardial stiffening, energetic inefficiency, and ultimately diastolic dysfuncti...
What the study was
- Study design
- Observational/unspecified
- Category
- Genomics/Precision Medicine
- Maturity
- Exploratory
- Journal
- Heart failure reviews
Why it surfaced
Score 5/10 [PROMISING_PRELIMINARY]: Observational/unspecified (Journal Article) matched 'Cardiovascular-metabolic: GLP-1, SGLT2, '. Components — novelty:1/3, relevance:2/3, design:1/2, population:1/2. Confidence: medium. Conservative scoring applied per v1.3 rubric.
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