Efficacy and safety of 5-aminolevulinic acid-guided surgery versus white-light resection in newly diagnosed glioblastoma: a systematic review and meta-analysis.
A specialized dye helps surgeons remove more glioblastoma tissue safely, potentially improving survival in patients with this aggressive brain cancer.
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumour in adults, characterized by diffuse infiltration and poor prognosis despite multimodal therapy. Maximal safe surgical resection remains the cornerstone of management, as greater extent of resection (EOR) correlates with improved survival.
What the study was
- Study design
- Randomized study
- Population
- patients
- Sample size
- 790
- Category
- Other
- Maturity
- Exploratory
- Journal
- Neurosurgical review
Why it surfaced
Score 8/10 [NEAR_TERM_IMPLEMENTABLE]: Randomized study (Journal Article) matched 'Hematologic malignancies (AML, MDS, CLL,'. Components — novelty:1/3, relevance:3/3, design:2/2, population:2/2. Confidence: high. Conservative scoring applied per v1.3 rubric.
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