📅 PUBMED DAILY TRIAGE — 2026-07-24 Window: 2026-07-23T00:00:00Z → 2026-07-24T09:00:00Z (CRDT) Topics scanned: 9 | Articles reviewed: 122 | Candidates evaluated: 122 High priority: 8 | Standard: 37 | Low/archive: 0 | Unsolicited finds: 3 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
• PM42493686 · Efficacy and safety of 5-aminolevulinic acid-guided surgery versus white-light resect · 8/10 🟢 ↳ Maximal safe surgical resection remains the cornerstone of management, as greater extent of resection (EOR) correlates w • PM42492906 · Co-mutation of asxl1 and IDH2R172K enhances leukemogenesis and correlates with epigen · 6/10 🟠 ↳ Co-mutations of asxl1 and IDH2 are associated with aggressive acute myeloid leukemia (AML), yet the underlying mechanism
CBC-based diagnostics and machine learning in hematology
No high-priority finds today (best candidate scored 5/10)
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
• PM42493692 · The COMPLETE-CRC Screening Initiative: Increasing Colonoscopy Completion After Positi · 6/10 🔴 ↳ S: Of 2,548 patients with positive SBT, 803 (31.5%) had not completed colonoscopy within 360 days. • PM42493241 · Bayesian Secondary Reanalysis of Published Aggregate Data on Circulating Tumor DNA fo · 6/10 🔴 ↳ s The prognostic analysis included 109 study arms (approximately 9,980 patients). • PM42492029 · Prognostic Significance of Cell-Free DNA Derived 5-Hydroxymethylcytosine Signatures i · 6/10 🔴 ↳ S: During a median follow-up of 70.5 months, 127 deaths occurred. • PM42491413 · A prediction model for urological tumor metastasis using liquid biopsy-derived biomar · 6/10 🔴 ↳ S: There was no significant difference in baseline data between the training set and the validation set (P > 0.05). • PM42492797 · Aptamer-Functionalized Nanomaterials for Circulating Tumor Cell Detection: From Liqui · 5/10 🔴 ↳ Finally, outstanding challenges in analytical robustness, biosafety, in vivo delivery, and clinical translation are disc
AI/ML in clinical diagnostics and imaging
No high-priority finds today (best candidate scored 7/10)
Precision oncology and genomic medicine
No high-priority finds today (best candidate scored 6/10)
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
No high-priority finds today (best candidate scored 6/10)
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
No high-priority finds today (best candidate scored 7/10)
Aging, longevity, and population health
No high-priority finds today (best candidate scored 6/10)
Rare diseases with high unmet need
No high-priority finds today (best candidate scored 6/10)
🟢⚪ STANDARD (4-7) — Top by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
• PM42493300 · Prognostic value of red blood cell distribution width for mortality in critically ill · 6/10 · Other • PM42492600 · Insurance Type and Quality of End-of-Life Care in Adults < 65 Years with Hematologic · 6/10 · Other • PM42493816 · Assessment of change in limb length following correction of coronal and sagittal plan · 5/10 · Other • PM42493693 · Necrobiotic Xanthogranuloma (NXG): Dermoscopic and Reflectance Confocal Microscopic F · 5/10 · Public Health • PM42492965 · Evaluation of the Prevalence of Myelodysplastic Syndromes and Associated Hematologic · 5/10 · Other
CBC-based diagnostics and machine learning in hematology
• PM42492965 · Evaluation of the Prevalence of Myelodysplastic Syndromes and Associated Hematologic · 5/10 · Other
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
• PM42491139 · The dual role of ion channels in diabetic kidney disease: a translational paradigm fo · 6/10 · Early Detection
AI/ML in clinical diagnostics and imaging
• PM42492159 · The application of artificial intelligence in healthcare practice: A mapping review o · 7/10 · Diagnostics • PM42492219 · Diagnostic accuracy of artificial intelligence-enhanced coronary CT angiography for d · 6/10 · Diagnostics • PM42492064 · Impact of Responsibility Allocation Structures on Diagnostic Quality in AI-Assisted D · 6/10 · Diagnostics • PM42491709 · Precision Nursing Device Management and Artificial Intelligence-Integrated Early Warn · 6/10 · Diagnostics • PM42493350 · The Value of Deep Learning in Differentiating Thyroid Adenomatoid Nodules on Ultrasou · 5/10 · Diagnostics
Precision oncology and genomic medicine
• PM42492669 · Governing Molecular Tumor Boards: Precision Funnel Analysis, Outcome Gap, and a Pay-a · 6/10 · Genomics/Precision Medicine • PM42490947 · Microbiome and cancer: mechanistic insights, diagnostic potential, and therapeutic st · 6/10 · Treatment Innovation • PM42493353 · Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and · 5/10 · Genomics/Precision Medicine • PM42492968 · KRAS-Driven Combined Pulmonary Adenocarcinoma and Atypical Carcinoid Tumor: A Rare Ca · 5/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
• PM42493491 · Krüppel-like factor 4 downregulation during esophageal cancer formation facilitates i · 6/10 · Treatment Innovation • PM42493434 · [Clinicopathological features and prognostic factors associated with long-term surviv · 6/10 · Treatment Innovation • PM42493213 · Randomized phase II trial of nivolumab and ipilimumab with or without stereotactic bo · 6/10 · Treatment Innovation • PM42492968 · KRAS-Driven Combined Pulmonary Adenocarcinoma and Atypical Carcinoid Tumor: A Rare Ca · 5/10 · Genomics/Precision Medicine • PM42493626 · Immunostimulatory lipogel implant enhances cancer immunotherapy. · 5/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
• PM42493728 · Impact of semaglutide on cognitive function in patients with type 2 diabetes and mild · 7/10 · Prevention • PM42493207 · Semaglutide for prevention of type 2 diabetes in women with postpartum prediabetes af · 6/10 · Prevention • PM42492718 · Transdiagnostic medication-associated weight gain across five effectiveness trials: a · 6/10 · Prevention • PM42493631 · A sex-specific perspective on coronary microvascular dysfunction in HFpEF: from vascu · 5/10 · Genomics/Precision Medicine • PM42492869 · Lymphocyte-derived microRNA hsa-miR-150-5p as a marker of inflammation-related kidney · 5/10 · Prevention
Aging, longevity, and population health
• PM42493464 · Advancing Geriatric Care in Japan: Integrating the 5Ms Framework With Comprehensive G · 6/10 · Public Health • PM42490996 · Immunoglobulin G in aging and cancer. · 6/10 · Public Health • PM42493198 · Effect of pictorial-based information about atherosclerosis on adherence to lifestyle · 5/10 · Prevention • PM42492920 · Digital Mahjong-Based Cognitive Engagement Intervention for Older Adults: Randomized · 5/10 · Public Health • PM42492087 · A Community-in-the-Loop Approach to Smart Home Monitoring for Aging in Place: Mixed M · 5/10 · Diagnostics
Rare diseases with high unmet need
• PM42491842 · Understanding Ehlers-Danlos Syndrome: A Claims-Based Analysis of Healthcare Cost Patt · 6/10 · Other • PM42489293 · Erdheim-Chester Disease Presenting as Optic Neuritis: A Case Report and Review of the · 6/10 · Prevention • PM42489130 · Updated Dutch 2026 Pediatric Differentiated Thyroid Carcinoma Guideline: Aligning wit · 6/10 · Public Health • PM42488236 · Racial Differences in Age at Diagnosis and Renal Manifestations of Antineutrophil Cyt · 6/10 · Drug Development • PM42487920 · Opportunities and challenges in automated coding of electronic health records: a pilo · 6/10 · Drug Development
💡 UNSOLICITED FINDS
• PM42491265 · Feasibility and safety profile of intranasal third-party allogeneic CD45RO(+)/RA(-) m · 7/10 🟠 ↳ S: Intranasal administration was completed as planned in all nine treated participants. • PM42492091 · The WISH 2.0 Intervention for Irritable Bowel Syndrome: Protocol for a Pilot Randomiz · 6/10 ⚪ ↳ S: The trial was approved by the Mass General Brigham Institutional Review Board and prospectively registered at Clinica • PM42492061 · Effects of cow placenta extract on cognitive function in aged dogs: a randomized cont · 5/10 ⚪ ↳ S: By month 6, the mean ± SD of CSLB was 35.1 ± 4.9 in the CPE group vs 41.1 ± 5.3 (P < .05; Cohen's d = -1.17; 95% CI f
📊 TODAY'S BREAKDOWN
By research category: Other: 7, Diagnostics: 6, Prevention: 6, Genomics/Precision Medicine: 6, Early Detection: 6, Treatment Innovation: 6, Public Health: 6, Drug Development: 2 By evidence maturity: Exploratory: 45 By species/model: human: 37, unknown: 5, animal: 3 By source type: peer_reviewed 45 | preprint 0 Topics with zero 8+ articles: CBC-based diagnostics and machine learning in hematology, AI/ML in clinical diagnostics and imaging, Novel therapeutics: immunotherapy, CAR-T, targeted therapy, Aging, longevity, and population health, Rare diseases with high unmet need
By watchlist topic (reviewed / kept / highest score): • Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): 15 reviewed / 13 kept / best 8/10 • CBC-based diagnostics and machine learning in hematology: 1 reviewed / 1 kept / best 5/10 • Early cancer detection (liquid biopsy, ctDNA, cfDNA): 15 reviewed / 15 kept / best 6/10 • AI/ML in clinical diagnostics and imaging: 15 reviewed / 15 kept / best 7/10 • Precision oncology and genomic medicine: 15 reviewed / 15 kept / best 6/10 • Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 15 kept / best 6/10 • Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 11 kept / best 7/10 • Aging, longevity, and population health: 15 reviewed / 15 kept / best 6/10 • Rare diseases with high unmet need: 6 reviewed / 6 kept / best 6/10 • Sentinel Scan (unsolicited finds): 10 reviewed / 10 kept / best 7/10
🔧 RUN NOTES
- Window: CRDT 2026-07-23→2026-07-24, no window expansion (all topics ≥1 result)
- CBC/ML hematology (T2): Only 1 raw result in window; unique PMID 42492965 already captured via T1 (hematologic malignancies). No fallback query needed.
- Rare diseases (T9): 6 raw results below 15-candidate cap — all 6 reviewed.
- Sentinel scan: 10 of 18 raw RCT/Phase-III clinical trial records selected; 3 unsolicited finds retained (score ≥6, not in any watchlist topic).
- Scoring: Rule-based heuristics v1.3; abstract-level classification. 45/45 articles had abstracts (no title-only records in final set).
- Corrections applied post-scoring:
- PMID 42491139: EARLY_CANCER_DETECTION flag removed — DKD review article, not cancer screening; flag was triggered by cfDNA biomarker terms in abstract. Corrected to PROMISING_PRELIMINARY / STANDARD.
- PMID 42492061: species_model corrected to 'animal' (dog RCT); 'clinical' keyword in abstract caused misclassification. Score capped at 5 per non-human rule.
- Coverage: esummary 113/113 PMIDs; efetch abstracts 107/113 (6 returned summary metadata only — still scored conservatively).
- Run status: SUCCESS (all topics had candidates; 10/10 per_topic_stats complete).
- No prior checkpoint: rolling 7-day zero-signal history unavailable for this run.