Neuropathology in a diverse cohort of oldest-old: The LifeAfter90 study.
Studying the oldest-old and diverse populations reveals how brain changes vary widely in extreme age, improving understanding of when dementia develops.
This report from the LifeAfter90 study characterizes neuropathological findings in a diverse cohort of adults aged 90+ with ante-mortem cognitive assessment, addressing the under-representation of oldest-old and diverse populations in dementia neuropathology research. The study reveals heterogeneous, multi-pathology profiles in the extreme elderly, with implications for understanding successful cognitive aging and establishing age-appropriate diagnostic criteria.
What the study was
- Study design
- Prospective neuropathological cohort
- Population
- Diverse cohort of oldest-old adults (age 90+) enrolled in the LifeAfter90 study; neuropathological examination at autopsy
- Category
- Other
- Maturity
- Exploratory
- Journal
- Alzheimer's & Dementia
Why it surfaced
Prospective neuropathological cohort in diverse oldest-old population from Alzheimer's & Dementia; high-impact journal; addresses understudied demographic with implications for cognitive aging research.
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